Amfecloral

Amfecloral
Systematic (IUPAC) name
2,2,2-trichloro-N-(1-phenylpropan-2-yl)ethanimine
Clinical data
Legal status
  • ?
Identifiers
CAS Number 5581-35-1 YesY
ATC code None
PubChem CID 21759
ChemSpider 20451 YesY
UNII 6015XOA0BI YesY
KEGG D02926 YesY
ChEMBL CHEMBL2105544 N
Synonyms alpha-methyl-N-(2,2,2-trichloroethylidene)phenethylamine;
N-(2,2,2-trichloroethylidene)amphetamine
Chemical data
Formula C11H12Cl3N
Molar mass 264.58 g/mol
 NYesY (what is this?)  (verify)

Amfecloral (INN), also known as amphecloral (USAN), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran, but is now no longer marketed.[1] It acts as a prodrug which splits to form amphetamine and chloral hydrate, similarly to clobenzorex and related compounds, except that the N-substituent in this case yields a compound that is active in its own right. The chloral hydrate metabolite is a gabaminergic sedative/hypnotic, and would in theory counteract some of the stimulant effects of the amphetamine metabolite. This would produce an effect similar to the amphetamine/barbiturate combinations previously used in psychiatric medications. Amfecloral can be prepared by the reaction of amphetamine with chloral hydrate.[2][3]

See also

References

  1. ↑ Ganellin, C. R.; Triggle, David J. (1996). Dictionary of pharmacological agents, Volumes 1-2. Chapman & Hall. p. 67. ISBN 0-9630096-0-5.
  2. ↑ C. Cavallito, U.S. Patent 2,923,661 (1960)
  3. ↑ Chem. Abstr., 54: 9846c (1966)


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