Alverine

Alverine

Systematic (IUPAC) name
N-Ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	150-59-4 Y
ATC code	A03AX08
PubChem	CID 3678
DrugBank	DB01616 Y
ChemSpider	3550 Y
UNII	46TIR1560O Y
KEGG	D07440 Y
ChEBI	CHEBI:518413 Y
ChEMBL	CHEMBL253371 Y
Chemical data
Formula	C20H27N
Molar mass	281.44 g/mol
SMILES c1ccccc1CCCN(CC)CCCc2ccccc2
InChI InChI=1S/C20H27N/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20/h3-8,11-14H,2,9-10,15-18H2,1H3 Y Key:ZPFXAOWNKLFJDN-UHFFFAOYSA-N Y
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Alverine is a drug used for functional gastrointestinal disorders. Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as heartburn, abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Alverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).

Alverine capsules^[1] are now available in the market. There are two strengths of capsule-60 mg and 120 mg. The common dosage for adults and children over 12 years is 60–120 mg taken one, two or three a day, either before or after meals. Alverine is not suitable for those aged under 12 years. Women who are pregnant or breast-feeding should follow the instruction of doctors for the drug.

The side effect of Alverine includes:^[2]

Difficulties in breathing or shortness of breath, wheezing, swelling of your face.

Yellowing of the whites of the eyes and the skin, as inflammation of the liver has been known to occur.

Other side effects include: sickness, headache, dizziness, allergic reaction includes inching and skin rash.

It was report that Alverine may induce toxic hepatitis.^[3][4]

Alverine citrate and simeticone(ACS) has been combined for Irritable Bowel Syndrome therapy, relating to safety and efficacy in the Clinical Trial Phase IV.^[5] At week 4, alverine citrate and simeticone group had lower VAS scores of abdominal pain⁄discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%,OR = 1.3; P = 0.01) as compared with placebo group.^[6]

The drug was firstly authorized for marketing on 03/06/2014. Marketing authorisation number(s) is PL 08553/0532. Marketing authorisation holder Dr. Reddy's Laboratories (UK) Ltd. ; 6 Riverview Road; Beverley; East Yorkshire; HU17 0LD; United Kingdom.^[7]

References