alpha-Hydroxyglutaric acid

α-Hydroxyglutaric acid
Names

IUPAC name 2-Hydroxypentanedioic acid
Other names 2-Hydroxyglutaric acid
Identifiers
CAS Number	2889-31-8^N
ChEBI	CHEBI:17084^Y
ChemSpider	42^Y
Jmol interactive 3D	Image Image
KEGG	C02630^Y
MeSH	Alpha-hydroxyglutarate
PubChem	43
InChI InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)^Y Key: HWXBTNAVRSUOJR-UHFFFAOYSA-N^Y InChI=1/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) Key: HWXBTNAVRSUOJR-UHFFFAOYAI
SMILES C(CC(=O)O)C(C(=O)O)O O=C(O)C(O)CCC(=O)O
Properties
Chemical formula	C₅H₈O₅
Molar mass	148.11 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.

This article is issued from Wikipedia - version of the Tuesday, July 07, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.