Allura Red AC

Allura Red AC
Names
IUPAC name
Disodium 6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfophenyl)azo]-2-naphthalenesulfonate
Other names
Allura Red; Food Red 17; C.I. 16035; FD&C Red 40; E129; 2-Naphthalenesulfonic acid, 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfophenyl)azo)-, disodium salt
Identifiers
25956-17-6 YesY
ChEMBL ChEMBL174821 N
ChemSpider 11588224 YesY
Jmol interactive 3D Image
PubChem 6093299
UNII WZB9127XOA YesY
Properties
C18H14N2Na2O8S2
Molar mass 496.42 g·mol−1
Appearance Red powder
Melting point > 300 °C (572 °F; 573 K)
Hazards
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
1
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Allura Red AC is a red azo dye that goes by several names including: Allura Red, Food Red 17, C.I. 16035, and FD&C Red 40.[1][2] It is used as a food dye and has the E number E129. Allura Red AC was originally introduced in the United States as a replacement for the use of amaranth as a food coloring.

It has the appearance of a dark red powder. It usually comes as a sodium salt, but can also be used as both calcium and potassium salts. It is soluble in water; in solution, its maximum absorbance lies at about 504 nm.[3]:921 Its melting point is above 300 °C (572 °F).

Health effects

Allura Red AC in confectionery
Allura Red AC in strawberry soft drink

Allura Red AC has fewer health risks associated with it in comparison to other azo dyes.

Red 40 has been linked to cancer in animals as well as reproductive issues.

Red 40 sensitivity (as an allergy) does exist in rare cases.

ADHD Controversy

Some sources say there is no evidence to support broad claims that food coloring causes food intolerance and ADHD-like behavior in children.[4]:452 Other sources say that certain food coloring may act as an ADHD trigger in those who are genetically predisposed, but the evidence is weak and not supported by the FDA.[5][6]

Regulation

Since the 1970s and the well-publicized advocacy of Benjamin Feingold, there has been public concern that food colorings may cause ADHD-like behavior in children.[5] These concerns have led the FDA and other food safety authorities to regularly review the scientific literature, and led the UK FSA to commission a study by researchers at Southampton University of the effect of a mixture of six food dyes (Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow and Carmoisine (dubbed the "Southampton 6")) and sodium benzoate (a preservative) on children in the general population, who consumed them in beverages; the study published in 2007.[5][7] The study found "a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity" in the children;[5][7] the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended".[5]

The European regulatory community, with a stronger emphasis on the precautionary principle, required labelling and temporarily reduced the acceptable daily intake (ADI) for the food colorings; the UK FSA called for voluntary withdrawal of the colorings by food manufacturers.[5][7] However in 2009 the EFSA re-evaluated the data at hand and determined that "the available scientific evidence does not substantiate a link between the color additives and behavioral effects"[5] and in 2014 after further review of the data, the EFSA restored the prior ADI levels.[8] In 2015, the EFSA found that the exposure estimates did not exceed the ADI of 7 mg/kg bw per day in any population.[9]

The US FDA did not make changes following the publication of the Southampton study, but following a citizen petition filed by the Center for Science in the Public Interest in 2008, requesting the FDA ban several food additives, the FDA commenced a review of the available evidence, and still made no changes.[5]

Allura Red AC was at one time banned in Denmark, Belgium, France and Switzerland, and was also banned in Sweden until the country joined the European Union in 1994.[10] The European Union approves Allura Red AC as a food colorant. In Norway, it was banned between 1978 and 2001, a period in which azo dyes were only legally used in alcoholic beverages and some fish products.[11]

In the United States, Allura Red AC is approved by the Food and Drug Administration (FDA) for use in cosmetics, drugs, and food. When prepared as a lake it is disclosed as Red 40 Lake or Red 40 Aluminum Lake. It is used in some tattoo inks and is used in many products, such as soft drinks, children's medications, and cotton candy. It is by far the most commonly used red dye in the United States, completely replacing amaranth (Red 2) and also replacing erythrosine (Red 3) in most applications due to the potential health effects of the two dyes.

References

  1. ↑ From Shampoo to Cereal: Seeing to the Safety of Color Additives at the Wayback Machine (archived January 15, 2008)
  2. ↑ Food Color Facts at the Wayback Machine (archived October 1, 2007)
  3. ↑ Zvi Rappoport, ed. (2004). The Chemistry of Phenols. Chichester: John Wiley & Sons. ISBN 9780470869451.
  4. ↑ Tomaska LD and Brooke-Taylor, S. Food Additives - General pp 449-454 in Encyclopedia of Food Safety, Vol 2: Hazards and Diseases. Eds, Motarjemi Y et al. Academic Press, 2013. ISBN 9780123786135
  5. 1 2 3 4 5 6 7 8 FDA. Background Document for the Food Advisory Committee: Certified Color Additives in Food and Possible Association with Attention Deficit Hyperactivity Disorder in Children: March 30-31, 2011
  6. ↑ Millichap JG, Yee MM (February 2012). "The diet factor in attention-deficit/hyperactivity disorder". Pediatrics 129 (2): 330–337. doi:10.1542/peds.2011-2199. PMID 22232312.
  7. 1 2 3 Sarah Chapman of Chapman Technologies on behalf of Food Standards Agency in Scotland. March 2011 [Guidelines on approaches to the replacement of Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow, Sunset Yellow and Carmoisine in food and beverages]
  8. ↑ EFSA Panel on Food Additives and Nutrient Sources added to food (ANS) Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110) EFSA Journal 2014;12(7):3765 . doi:10.2903/j.efsa.2014.3765
  9. ↑ http://www.efsa.europa.eu/en/efsajournal/pub/4007
  10. ↑ "E129", UK Food Guide, a British food additives website. Last retrieved 20 May 2007.
  11. ↑ Norwegian Food Safety Authority

External links

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