Aldehyde dehydrogenase 9 family, member A1
4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[1][2][3]
This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[3]
References
- ↑ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (Mar 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Hum Genet 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751.
- ↑ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (Sep 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
- 1 2 "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".
Further reading
- Kurys G, Ambroziak W, Pietruszko R (1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.". J. Biol. Chem. 264 (8): 4715–21. PMID 2925663.
- Kurys G, Shah PC, Kikonygo A; et al. (1994). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde.". Eur. J. Biochem. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
- Kikonyogo A, Pietruszko R (1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution.". Biochem. J. 316 (1): 317–24. PMC 1217341. PMID 8645224.
- Izaguirre G, Kikonyogo A, Pietruszko R (1998). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution.". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
- Vaz FM, Fouchier SW, Ofman R; et al. (2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.". J. Biol. Chem. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
- Izaguirre G, Pietruszko R, Cho S, MacKerell A (2002). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs.". J. Biomol. Struct. Dyn. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
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