Adhyperforin

Adhyperforin
Systematic (IUPAC) name
(1R,5S,6R,7S)-4-Hydroxy-6-methyl-5-(2-methylbutanoyl)-1,3,7-tris(3-methyl-2-buten-1-yl)-6-(4-methyl-3-penten-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
Clinical data
Legal status
  • Over-the-counter
Routes of
administration		 Oral
Identifiers
CAS Number 143183-63-5 N
ATC code None
PubChem CID 9963735
ChemSpider 25066875 N
ChEMBL CHEMBL388948 YesY
Chemical data
Formula C36H54O4
Molar mass 550.81156 g/mol
 NYesY (what is this?)  (verify)

Adhyperforin is a phytochemical found in the members of the plant genus Hypericum including St. John's Wort.[1] It has a very similar pharmacological profile to hyperforin and acts as a TRPC6 ion channel activator,[1] thereby inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate.[1] Adhyperforin is found in St. John's Wort in levels approximately 1/10 those of hyperforin.[1]

See also

References

  1. 1 2 3 4 Jensen AG, Hansen SH, Nielsen EO. (2001). "Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.". Life Sci. 68 (14): 1593–1605. doi:10.1016/S0024-3205(01)00946-8. PMID 11263672.


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