Acetyl-CoA C-acetyltransferase
In enzymology, an acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction
- 2 acetyl-CoA CoA + acetoacetyl-CoA
Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA.
Acetyl-CoA C-acetyltransferase belongs to the thiolase family of enzymes.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.
Isozymes
Human genes encoding acetyl-CoA C-acetyltransferases include:
References
- ↑ PDB: 2WKT; Meriläinen G, Poikela V, Kursula P, Wierenga RK (November 2009). "The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation". Biochemistry 48 (46): 11011–25. doi:10.1021/bi901069h. PMID 19842716.
Further reading
- LYNEN F, OCHOA S (1953). "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta 12 (1-2): 299–314. doi:10.1016/0006-3002(53)90149-8. PMID 13115439.
- Stern JR, Drummond GI, Coon MJ and del Campillo A (1960). "Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver". J. Biol. Chem. 235: 313–317. PMID 13834445.
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