Acetone carboxylase
| acetone carboxylase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.4.1.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an acetone carboxylase (EC 6.4.1.6) is an enzyme that catalyzes the chemical reaction
- acetone + CO2 + ATP + 2 H2O
acetoacetate + AMP + 2 phosphate
The 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).
References
- Sluis MK, Ensign SA (1997). "Purification and characterization of acetone carboxylase from Xanthobacter strain Py2". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8456–61. doi:10.1073/pnas.94.16.8456. PMC 22955. PMID 9237998.
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