Acefurtiamine

Acefurtiamine
Systematic (IUPAC) name

(3E)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-[(furan-2-ylcarbonyl)sulfanyl]pent-3-en-1-yl (acetyloxy)acetate
Identifiers
CAS Number	10072-48-7^N
ATC code	None
PubChem	CID 3037171
ChemSpider	2300987^Y
UNII	6APJ3D1308^Y
ChEMBL	CHEMBL2104090^N
Chemical data
Formula	C₂₁H₂₄N₄O₇S
Molar mass	476.503 g/mol
SMILES O=C(OCC(=O)OCCC(\SC(=O)c1occc1)=C(/N(C=O)Cc2cnc(nc2N)C)C)C
InChI InChI=1S/C21H24N4O7S/c1-13(25(12-26)10-16-9-23-14(2)24-20(16)22)18(33-21(29)17-5-4-7-30-17)6-8-31-19(28)11-32-15(3)27/h4-5,7,9,12H,6,8,10-11H2,1-3H3,(H2,22,23,24)/b18-13+^Y Key:MYBUGVXNAHWTOL-QGOAFFKASA-N^Y
^NY (what is this?) (verify)

Acefurtiamine (INN) is an analogue of vitamin B₁ (in a manner similar to the GABAergic activity of the thiamine derivative clomethiazole^[1] which functions as an analgesic agent at sufficient doses {Dosage Range Unlisted}).

References

↑ William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences (1993). The Extra Pharmacopoeia. Pharmaceutical Press. p. 1053. ISBN 978-0-85369-300-0.

Vitamins (A11)

Fat soluble

A	α-Carotene β-Carotene Retinol^# Tretinoin

D	D₂ Ergosterol Ergocalciferol^# D₃ 7-Dehydrocholesterol Previtamin D₃ Cholecalciferol 25-hydroxycholecalciferol Calcitriol (1,25-dihydroxycholecalciferol) Calcitroic acid D₄ Dihydroergocalciferol D₅ D analogues Alfacalcidol Dihydrotachysterol Calcipotriol Tacalcitol Paricalcitol

E	Tocopherol Alpha Beta Gamma Delta Tocotrienol Alpha Beta Gamma Delta Tocofersolan

K	Naphthoquinone Phylloquinone (K₁) Menaquinones (K₂) Menadione (K₃)‡ Menadiol (K₄)

Water soluble

B	B₁ Thiamine^# B₁ analogues Acefurtiamine Allithiamine Benfotiamine Fursultiamine Octotiamine Prosultiamine Sulbutiamine B₂ Riboflavin^# B₃ Niacin Nicotinamide^# B₅ Pantothenic acid Dexpanthenol Pantethine B₆ Pyridoxine^#, Pyridoxal phosphate Pyridoxamine Pyritinol B₇ Biotin B₉ Folic acid Dihydrofolic acid Folinic acid Levomefolic acid B₁₂ Cyanocobalamin Hydroxocobalamin Methylcobalamin Cobamamide Choline

C	Ascorbic acid^# Dehydroascorbic acid

Combinations

Multivitamins

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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Acefurtiamine

See also

References