ATP5C1

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

PDB rendering based on 1bmf.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1bmf, 1cow, 1e1q, 1e1r, 1e79, 1efr, 1h8e, 1h8h, 1mab, 1nbm, 1ohh, 1qo1, 1w0j, 1w0k, 2ck3, 2f43, 2jdi

Identifiers

Symbols

ATP5C1 ; ATP5C; ATP5CL1

External IDs

OMIM: 108729 MGI: 1261437 HomoloGene: 3792 GeneCards: ATP5C1 Gene

EC number

3.6.1.14

Gene ontology
Molecular function	• ATPase activity • transmembrane transporter activity • poly(A) RNA binding • proton-transporting ATP synthase activity, rotational mechanism • proton-transporting ATPase activity, rotational mechanism
Cellular component	• mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) • mitochondrion • mitochondrial inner membrane • mitochondrial proton-transporting ATP synthase complex • mitochondrial matrix • membrane • myelin sheath • extracellular exosome
Biological process	• oxidative phosphorylation • ATP biosynthetic process • respiratory electron transport chain • mitochondrial ATP synthesis coupled proton transport • cellular metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

509

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
7.79 – 7.81 Mb

Chr 2:
10.06 – 10.08 Mb

PubMed search

The human ATP5C1 gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.^[1]^[2]^[3]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate(ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation.

ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core.

Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.^[3]

References

↑ Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843.
↑ Matsuda C, Endo H, Ohta S, Kagawa Y (Dec 1993). "Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing". J Biol Chem 268 (33): 24950–8. PMID 8227057.
1 2 "Entrez Gene: ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1".

Yoshida M, Muneyuki E, Hisabori T (2001). "ATP synthase--a marvellous rotary engine of the cell". Nat. Rev. Mol. Cell Biol. 2 (9): 669–77. doi:10.1038/35089509. PMID 11533724.
Abrahams JP, Leslie AG, Lutter R, Walker JE (1994). "Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria". Nature 370 (6491): 621–8. doi:10.1038/370621a0. PMID 8065448.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
Yasuda R, Noji H, Kinosita K, Yoshida M (1998). "F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps". Cell 93 (7): 1117–24. doi:10.1016/S0092-8674(00)81456-7. PMID 9657145.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
Hayakawa M, Sakashita E, Ueno E, et al. (2002). "Muscle-specific exonic splicing silencer for exon exclusion in human ATP synthase gamma-subunit pre-mRNA". J. Biol. Chem. 277 (9): 6974–84. doi:10.1074/jbc.M110138200. PMID 11744705.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cross RL (2004). "Molecular motors: turning the ATP motor". Nature 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
Itoh H, Takahashi A, Adachi K, et al. (2004). "Mechanically driven ATP synthesis by F1-ATPase". Nature 427 (6973): 465–8. doi:10.1038/nature02212. PMID 14749837.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Fukumura K, Kato A, Jin Y, et al. (2007). "Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1γ gene". Nucleic Acids Res. 35 (16): 5303–11. doi:10.1093/nar/gkm569. PMC 2018636. PMID 17686786.

PDB gallery

1bmf: BOVINE MITOCHONDRIAL F1-ATPASE

1cow: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B

1e1q: BOVINE MITOCHONDRIAL F1-ATPASE AT 100K

1e1r: BOVINE MITOCHONDRIAL F1-ATPASE INHIBITED BY MG2+ADP AND ALUMINIUM FLUORIDE

1e79: BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)

1efr: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE PEPTIDE ANTIBIOTIC EFRAPEPTIN

1h8e: (ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)

1h8h: BOVINE MITOCHONDRIAL F1-ATPASE CRYSTALLISED IN THE PRESENCE OF 5MM AMPPNP

1mab: RAT LIVER F1-ATPASE

1nbm: THE STRUCTURE OF BOVINE F1-ATPASE COVALENTLY INHIBITED WITH 4-CHLORO-7-NITROBENZOFURAZAN

1ohh: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE INHIBITOR PROTEIN IF1

1w0j: BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE

1w0k: BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE

2ck3: AZIDE INHIBITED BOVINE F1-ATPASE

2f43: Rat liver F1-ATPase

2jdi: GROUND STATE STRUCTURE OF F1-ATPASE FROM BOVINE HEART MITOCHONDRIA (BOVINE F1-ATPASE CRYSTALLISED IN THE ABSENCE OF AZIDE)

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ATP5C1

References

Further reading