ARID5B
AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.[1][2][3]
Alternative names for this gene include Modulator recognition factor 23.
Genomics
The gene is located on the long arm of chromosome 10 (10q21.2) on the Watson (plus) strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilo Daltons respectively.
Clinical importance
This gene has been associated with childhood leukaemia.
References
- ↑ Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Res 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.
- ↑ Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Jul 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.
- ↑ "Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like)".
Further reading
- Yuan YC, Whitson RH, Liu Q; et al. (1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases.". Nat. Struct. Biol. 5 (11): 959–64. doi:10.1038/2934. PMID 9808040.
- Whitson RH, Huang T, Itakura K (1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts.". Biochem. Biophys. Res. Commun. 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins.". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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