APBB1IP
| Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | APBB1IP ; INAG1; PREL1; RARP1; RIAM | ||||||||||||
| External IDs | OMIM: 609036 MGI: 1861354 HomoloGene: 32434 GeneCards: APBB1IP Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54518 | 54519 | |||||||||||
| Ensembl | ENSG00000077420 | ENSMUSG00000026786 | |||||||||||
| UniProt | Q7Z5R6 | Q8R5A3 | |||||||||||
| RefSeq (mRNA) | NM_019043 | NM_019456 | |||||||||||
| RefSeq (protein) | NP_061916 | NP_062329 | |||||||||||
| Location (UCSC) |
Chr 10: 26.44 – 26.57 Mb |
Chr 2: 22.77 – 22.88 Mb | |||||||||||
| PubMed search | |||||||||||||
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.[1][2][3]
References
- ↑ "Entrez Gene: amyloid beta (A4) precursor protein-binding".
- ↑ Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi:10.1074/jbc.M308016200. PMID 14530287.
- ↑ Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. PMID 15469846.
Further reading
- Lee HS, Lim CJ, Puzon-McLaughlin W; et al. (2009). "RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.". J. Biol. Chem. 284 (8): 5119–27. doi:10.1074/jbc.M807117200. PMC 2643525. PMID 19098287.
- Ermekova KS, Zambrano N, Linn H; et al. (1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
- Rose JE, Behm FM, Drgon T; et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Morgan AR, Turic D, Jehu L; et al. (2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6): 762–70. doi:10.1002/ajmg.b.30509. PMID 17373700.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jenzora A, Behrendt B, Small JV; et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358.
- Grupe A, Li Y, Rowland C; et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Patsoukis N, Lafuente EM, Meraner P; et al. (2009). "RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.". Sci Signal 2 (99): ra79. doi:10.1126/scisignal.2000409. PMC 2908902. PMID 19952372.
- Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Linkermann A, Gelhaus C, Lettau M; et al. (2009). "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.". Biochim. Biophys. Acta 1794 (2): 168–76. doi:10.1016/j.bbapap.2008.10.013. PMID 19041431.
- Defilippi P, Di Stefano P, Cabodi S (2006). "p130Cas: a versatile scaffold in signaling networks.". Trends Cell Biol. 16 (5): 257–63. doi:10.1016/j.tcb.2006.03.003. PMID 16581250.
- Shattil SJ (2005). "Integrins and Src: dynamic duo of adhesion signaling.". Trends Cell Biol. 15 (8): 399–403. doi:10.1016/j.tcb.2005.06.005. PMID 16005629.
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