AP2A2

Adaptor-related protein complex 2, alpha 2 subunit

PDB rendering based on 1b9k.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1b9k, 1gw5, 1ky6, 1ky7, 1kyd, 1kyf, 1kyu, 1qtp, 1qts, 1w80

Identifiers

Symbols

AP2A2 ; ADTAB; CLAPA2; HIP-9; HIP9; HYPJ

External IDs

OMIM: 607242 MGI: 101920 HomoloGene: 5335 GeneCards: AP2A2 Gene

Gene ontology
Molecular function	• molecular_function • protein binding • lipid binding • protein transporter activity • protein kinase binding • protein complex binding • clathrin adaptor activity
Cellular component	• cytosol • plasma membrane • cytoplasmic membrane-bounded vesicle • AP-2 adaptor complex • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane
Biological process	• intracellular protein transport • epidermal growth factor receptor signaling pathway • synaptic transmission • axon guidance • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • negative regulation of epidermal growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • regulation of defense response to virus by virus • clathrin-mediated endocytosis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

161

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
0.92 – 1.01 Mb

Chr 7:
141.56 – 141.63 Mb

PubMed search

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.^[1]^[2]^[3]

Interactions

AP2A2 has been shown to interact with EPN1^[4] and SHC1.^[5]

References

↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
↑ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".
↑ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
↑ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.

Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals". Proceedings of the National Academy of Sciences of the United States of America 93 (1): 331–5. doi:10.1073/pnas.93.1.331. PMC 40232. PMID 8552632.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.
Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". The Journal of Biological Chemistry 271 (20): 12111–6. doi:10.1074/jbc.271.20.12111. PMID 8662627.
van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (Feb 1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". The Journal of Cell Biology 136 (4): 811–21. doi:10.1083/jcb.136.4.811. PMC 2132490. PMID 9049247.
Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (Jun 1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". The Journal of Biological Chemistry 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology 73 (2): 1350–61. PMC 103959. PMID 9882340.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America 96 (16): 8907–12. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Slepnev VI, Ochoa GC, Butler MH, De Camilli P (Jun 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (Aug 2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis". Journal of Cell Science. 113 ( Pt 16) (16): 2837–44. PMID 10910768.

PDB gallery

1b9k: ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2

1gw5:

1ky6: AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE

1ky7: THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF

1kyd: AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE

1kyf: AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE

1kyu: AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE

1qtp: CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE

1qts: CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE

1w80: CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, BOUND TO 2 PEPTIDES FROM SYNAPTOJANIN170

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AP2A2

Interactions

References

Further reading