AP1M1

Adaptor-related protein complex 1, mu 1 subunit

PDB rendering based on 1w63.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1w63

Identifiers

Symbols

AP1M1 ; AP47; CLAPM2; CLTNM; MU-1A

External IDs

OMIM: 603535 MGI: 102776 HomoloGene: 4017 GeneCards: AP1M1 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• Golgi membrane • lysosomal membrane • cytosol • membrane • clathrin adaptor complex • cytoplasmic vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane • extracellular exosome
Biological process	• intracellular protein transport • post-Golgi vesicle-mediated transport • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • melanosome organization • endosome to melanosome transport • regulation of defense response to virus by virus • membrane organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
16.2 – 16.25 Mb

Chr 8:
72.24 – 72.26 Mb

PubMed search

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.^[1]^[2]

Function

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.^[3]

Interactions

AP1M1 has been shown to interact with VAMP4^[4] and AP1G1.^[5]^[6]

References

↑ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
↑ Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Jan 2008). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin". Traffic 9 (1): 121–32. doi:10.1111/j.1600-0854.2007.00672.x. PMID 17988225.
↑ "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit".
↑ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
↑ Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
↑ Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.

Geyer M, Fackler OT, Peterlin BM (Jul 2001). "Structure--function relationships in HIV-1 Nef". EMBO Reports 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
Bénichou S, Benmerah A (Jan 2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Médecine Sciences 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (Sep 1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
Seaman MN, Sowerby PJ, Robinson MS (Oct 1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network". The Journal of Biological Chemistry 271 (41): 25446–51. doi:10.1074/jbc.271.41.25446. PMID 8810314.
Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D (Jan 1997). "The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane". Immunity 6 (1): 67–77. doi:10.1016/S1074-7613(00)80243-5. PMID 9052838.
Foti M, Mangasarian A, Piguet V, Lew DP, Krause KH, Trono D, Carpentier JL (Oct 1997). "Nef-mediated clathrin-coated pit formation". The Journal of Cell Biology 139 (1): 37–47. doi:10.1083/jcb.139.1.37. PMC 2139808. PMID 9314527.
Ohno H, Aguilar RC, Fournier MC, Hennecke S, Cosson P, Bonifacino JS (Nov 1997). "Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family". Virology 238 (2): 305–15. doi:10.1006/viro.1997.8839. PMID 9400603.
Piguet V, Chen YL, Mangasarian A, Foti M, Carpentier JL, Trono D (May 1998). "Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes". The EMBO Journal 17 (9): 2472–81. doi:10.1093/emboj/17.9.2472. PMC 1170589. PMID 9564030.
Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O (Apr 1998). "Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules". Immunity 8 (4): 483–95. doi:10.1016/S1074-7613(00)80553-1. PMID 9586638.
Craig HM, Pandori MW, Guatelli JC (Sep 1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proceedings of the National Academy of Sciences of the United States of America 95 (19): 11229–34. doi:10.1073/pnas.95.19.11229. PMC 21624. PMID 9736718.
Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC (Nov 1998). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Current Biology 8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID 9811606.
Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T (Nov 1998). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Current Biology 8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611.
Owen DJ, Evans PR (Nov 1998). "A structural explanation for the recognition of tyrosine-based endocytotic signals". Science 282 (5392): 1327–32. doi:10.1126/science.282.5392.1327. PMID 9812899.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology 73 (2): 1350–61. PMC 103959. PMID 9882340.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
Orzech E, Cohen S, Weiss A, Aroeti B (May 2000). "Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells". The Journal of Biological Chemistry 275 (20): 15207–19. doi:10.1074/jbc.275.20.15207. PMID 10809756.
Umeda A, Meyerholz A, Ungewickell E (May 2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation". European Journal of Cell Biology 79 (5): 336–42. doi:10.1078/S0171-9335(04)70037-0. PMID 10887964.
Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Nov 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728.

PDB gallery

1w63: AP1 CLATHRIN ADAPTOR CORE

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AP1M1

Function

Interactions

References

Further reading