AP1G1

Adaptor-related protein complex 1, gamma 1 subunit

PDB rendering based on 1gyu.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1IU1

Identifiers

Symbols

AP1G1 ; ADTG; CLAPG1

External IDs

OMIM: 603533 MGI: 101919 HomoloGene: 47995 GeneCards: AP1G1 Gene

Gene ontology
Molecular function	• transporter activity • protein binding • protein transporter activity • Rab GTPase binding • kinesin binding • GTP-dependent protein binding
Cellular component	• Golgi membrane • cytoplasm • lysosomal membrane • Golgi apparatus • cytosol • membrane • AP-type membrane coat adaptor complex • clathrin adaptor complex • clathrin-coated vesicle • cytoplasmic vesicle membrane • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane • intracellular membrane-bounded organelle • perinuclear region of cytoplasm • recycling endosome
Biological process	• intracellular protein transport • post-Golgi vesicle-mediated transport • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • melanosome organization • endosome to melanosome transport • positive regulation of natural killer cell degranulation • positive regulation of natural killer cell mediated cytotoxicity • regulation of defense response to virus by virus • membrane organization • Golgi to lysosome transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

164

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
71.73 – 71.81 Mb

Chr 8:
109.78 – 109.86 Mb

PubMed search

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.^[1]^[2]

Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

AP1G1 has been shown to interact with:

References

↑ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
1 2 3 Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
↑ "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit".
1 2 3 Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/s0092-8674(00)81650-5. PMID 10535737.
1 2 3 Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
1 2 Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876.
↑ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
↑ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". The Journal of Biological Chemistry 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
↑ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
↑ Horikawa HP, Kneussel M, El Far O, Betz H (Nov 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Molecular and Cellular Neurosciences 21 (3): 454–62. doi:10.1006/mcne.2002.1191. PMID 12498786.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology 73 (2): 1350–61. PMC 103959. PMID 9882340.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Nov 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728.
Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M (Mar 2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". Journal of Virology 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G (May 2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". The EMBO Journal 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC 125242. PMID 11331585.
Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K (Jun 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochemical and Biophysical Research Communications 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, Weiss A, Melamed-Book N, Lebendiker M, Altschuler Y, Aroeti B (Aug 2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". The Journal of Biological Chemistry 276 (33): 31340–8. doi:10.1074/jbc.M101054200. PMID 11418592.
Doray B, Kornfeld S (Jul 2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Molecular Biology of the Cell 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC 55640. PMID 11451993.
Shiba Y, Takatsu H, Shin HW, Nakayama K (Mar 2002). "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain". Journal of Biochemistry 131 (3): 327–36. doi:10.1093/oxfordjournals.jbchem.a003107. PMID 11872161.
Austin C, Boehm M, Tooze SA (Apr 2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry 41 (14): 4669–77. doi:10.1021/bi016064j. PMID 11926829.
Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (Jul 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry 277 (28): 25400–7. doi:10.1074/jbc.M110793200. PMID 11950833.
Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876.
Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.

PDB gallery

1gyu: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1

1gyv: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT

1gyw: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT

1iu1: Crystal structure of human gamma1-adaptin ear domain

1w63: AP1 CLATHRIN ADAPTOR CORE

2a7b: On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength

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AP1G1

Function

Interactions

References

Further reading