ALG3

ALG3, alpha-1,3- mannosyltransferase
Identifiers
Symbols ALG3 ; CDG1D; CDGS4; CDGS6; D16Ertd36e; NOT56L; Not56; not
External IDs OMIM: 608750 MGI: 1098592 HomoloGene: 4228 GeneCards: ALG3 Gene
EC number 2.4.1.258
Orthologs
Species Human Mouse
Entrez 10195 208624
Ensembl ENSG00000214160 ENSMUSG00000033809
UniProt Q92685 Q8K2A8
RefSeq (mRNA) NM_001006940 NM_145939
RefSeq (protein) NP_001006942 NP_666051
Location (UCSC) Chr 3:
184.24 – 184.25 Mb
Chr 16:
20.61 – 20.61 Mb
PubMed search

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that in humans is encoded by the ALG3 gene.[1][2]

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.[2]

References

  1. Jerrold LE (Dec 1975). "Will an electric current replace the syringe for anesthesia?". Dent Stud 53 (5): 49, 54. PMID 1058125.
  2. 1 2 "Entrez Gene: ALG3 asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)".

Further reading

External links


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