AFAP1
| Actin filament associated protein 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | AFAP1 ; AFAP; AFAP-110; AFAP110 | ||||||||||||
| External IDs | OMIM: 608252 MGI: 1917542 HomoloGene: 11009 GeneCards: AFAP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 60312 | 70292 | |||||||||||
| Ensembl | ENSG00000196526 | ENSMUSG00000029094 | |||||||||||
| UniProt | Q8N556 | Q80YS6 | |||||||||||
| RefSeq (mRNA) | NM_001134647 | NM_027373 | |||||||||||
| RefSeq (protein) | NP_001128119 | NP_081649 | |||||||||||
| Location (UCSC) |
Chr 4: 7.76 – 7.94 Mb |
Chr 5: 35.89 – 36 Mb | |||||||||||
| PubMed search | |||||||||||||
Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[1][2][3][4]
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[4]
References
- ↑ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.
- ↑ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.
- ↑ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
- 1 2 "Entrez Gene: AFAP1 actin filament associated protein 1".
Further reading
- Ishida Y, Hadano S, Nagayama T; et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p.". Genomics 22 (2): 302–12. doi:10.1006/geno.1994.1388. PMID 7545969.
- Qian Y, Baisden JM, Westin EH; et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity.". Oncogene 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827.
- Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif.". Mol. Carcinog. 22 (2): 110–9. doi:10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q. PMID 9655255.
- Qian Y, Baisden JM, Zot HG; et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation.". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.
- Qian Y, Baisden JM, Cherezova L; et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.". Mol. Biol. Cell 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMC 117315. PMID 12134071.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Dorfleutner A, Stehlik C, Zhang J; et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.". J. Cell. Physiol. 213 (3): 740–9. doi:10.1002/jcp.21143. PMID 17520695.
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