ADH1C
| Alcohol dehydrogenase 1C (class I), gamma polypeptide | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
PDB rendering based on 1deh. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | ADH1C ; ADH3 | ||||||||||||
| External IDs | OMIM: 103730 MGI: 87921 HomoloGene: 73888 ChEMBL: 3285 GeneCards: ADH1C Gene | ||||||||||||
| EC number | 1.1.1.1 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 126 | 11522 | |||||||||||
| Ensembl | ENSG00000248144 | ENSMUSG00000074207 | |||||||||||
| UniProt | P00326 | P00329 | |||||||||||
| RefSeq (mRNA) | NM_000669 | NM_007409 | |||||||||||
| RefSeq (protein) | NP_000660 | NP_031435 | |||||||||||
| Location (UCSC) |
Chr 4: 99.34 – 99.35 Mb |
Chr 3: 138.26 – 138.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[1]
Function
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[2]
References
- ↑ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Advances in Human Genetics 15: 249–90. doi:10.1007/978-1-4615-8356-1_5. PMID 3006456.
- ↑ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".
Further reading
- Seitz HK, Meier P (Jun 2007). "The role of acetaldehyde in upper digestive tract cancer in alcoholics". Translational Research 149 (6): 293–7. doi:10.1016/j.trsl.2006.12.002. PMID 17543846.
- Lange LG, Sytkowski AJ, Vallee BL (Oct 1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
- Yokoyama S, Matsuo Y, Rajasekharan S, Yokoyama R (Apr 1992). "Molecular structure of the human alcohol dehydrogenase 3 gene". Idengaku Zasshi 67 (2): 167–71. doi:10.1266/jjg.67.167. PMID 1524834.
- Hurley TD, Bosron WF, Hamilton JA, Amzel LM (Sep 1991). "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions". Proceedings of the National Academy of Sciences of the United States of America 88 (18): 8149–53. doi:10.1073/pnas.88.18.8149. PMC 52464. PMID 1896463.
- Stewart MJ, McBride MS, Winter LA, Duester G (Jun 1990). "Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box". Gene 90 (2): 271–9. doi:10.1016/0378-1119(90)90190-3. PMID 2169444.
- Yasunami M, Kikuchi I, Sarapata D, Yoshida A (Jun 1990). "The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome". Genomics 7 (2): 152–8. doi:10.1016/0888-7543(90)90535-3. PMID 2347582.
- Tsukahara M, Yoshida A (Feb 1989). "Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization". Genomics 4 (2): 218–20. doi:10.1016/0888-7543(89)90304-2. PMID 2737681.
- Ikuta T, Szeto S, Yoshida A (Feb 1986). "Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence". Proceedings of the National Academy of Sciences of the United States of America 83 (3): 634–8. doi:10.1073/pnas.83.3.634. PMC 322918. PMID 2935875.
- Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (Apr 1988). "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification". Genomics 2 (3): 209–14. doi:10.1016/0888-7543(88)90004-3. PMID 3397059.
- Höög JO, Hedén LO, Larsson K, Jörnvall H, von Bahr-Lindström H (Sep 1986). "The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties". European Journal of Biochemistry / FEBS 159 (2): 215–8. doi:10.1111/j.1432-1033.1986.tb09855.x. PMID 3758060.
- Bühler R, Hempel J, Kaiser R, de Zalenski C, von Wartburg JP, Jörnvall H (Dec 1984). "Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain". European Journal of Biochemistry / FEBS 145 (3): 447–53. doi:10.1111/j.1432-1033.1984.tb08575.x. PMID 6391921.
- Cheung B, Anderson JK, Holmes RS, Beacham IR (Feb 1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcoholism: Clinical and Experimental Research 19 (1): 185–6. doi:10.1111/j.1530-0277.1995.tb01490.x. PMID 7771649.
- Hurley TD, Bosron WF, Stone CL, Amzel LM (Jun 1994). "Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences". Journal of Molecular Biology 239 (3): 415–29. doi:10.1006/jmbi.1994.1382. PMID 8201622.
- Cheung C, Smith CK, Hoog JO, Hotchkiss SA (Jul 1999). "Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin". Biochemical and Biophysical Research Communications 261 (1): 100–7. doi:10.1006/bbrc.1999.0943. PMID 10405330.
- Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H (Aug 1999). "Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family". Biochemical Pharmacology 58 (3): 389–95. doi:10.1016/S0006-2952(99)00065-9. PMID 10424757.
- Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD (Apr 2001). "Three-dimensional structures of the three human class I alcohol dehydrogenases". Protein Science 10 (4): 697–706. doi:10.1110/ps.45001. PMC 2373965. PMID 11274460.
- Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK (Dec 2002). "A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans". Alcoholism: Clinical and Experimental Research 26 (12): 1759–63. doi:10.1097/01.ALC.0000042013.13899.75. PMID 12500098.
| |||||||||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the Monday, February 15, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.