ADCY8

Adenylate cyclase 8 (brain)

Identifiers

ADCY8 ; AC8; ADCY3; HBAC1

External IDs

OMIM: 103070 MGI: 1341110 HomoloGene: 37443 ChEMBL: 2960 GeneCards: ADCY8 Gene

4.6.1.1

Gene ontology
Molecular function	• adenylate cyclase activity • ATP binding • calcium- and calmodulin-responsive adenylate cyclase activity • metal ion binding
Cellular component	• intracellular • plasma membrane • membrane • integral component of membrane
Biological process	• renal water homeostasis • energy reserve metabolic process • cAMP biosynthetic process • water transport • signal transduction • epidermal growth factor receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • learning or memory • long-term memory • fibroblast growth factor receptor signaling pathway • activation of protein kinase A activity • intracellular signal transduction • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • transmembrane transport • cellular response to glucagon stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

114

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
130.78 – 131.04 Mb

Chr 15:
64.7 – 64.92 Mb

PubMed search

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.^[1]^[2]

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (R_s and R_i) interact with G proteins (G_s and G_i) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.^[2]

References

↑ Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676.
1 2 "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

Stengel D, Parma J, Gannagé MH, Roeckel N, Mattei MG, Barouki R, Hanoune J (1992). "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain". Human Genetics 90 (1-2): 126–30. doi:10.1007/BF00210755. PMID 1427768.
Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J (Aug 1991). "Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain". Biochemical and Biophysical Research Communications 179 (1): 455–62. doi:10.1016/0006-291X(91)91392-P. PMID 1715695.
Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J (Apr 1994). "Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain". The Journal of Biological Chemistry 269 (16): 12190–5. PMID 8163524.
Gu C, Cooper DM (Mar 1999). "Calmodulin-binding sites on adenylyl cyclase type VIII". The Journal of Biological Chemistry 274 (12): 8012–21. doi:10.1074/jbc.274.12.8012. PMID 10075700.
Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
Parkinson NA, Bolsover SR (Jul 2001). "A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones". Brain Research. Molecular Brain Research 91 (1-2): 43–9. doi:10.1016/S0169-328X(01)00119-X. PMID 11457491.
Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research 22 (1-4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
Georget M, Mateo P, Vandecasteele G, Lipskaia L, Defer N, Hanoune J, Hoerter J, Lugnier C, Fischmeister R (Aug 2003). "Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)". FASEB Journal 17 (11): 1380–91. doi:10.1096/fj.02-0784com. PMID 12890691.
Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM (Feb 2006). "A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A". Molecular Pharmacology 69 (2): 608–17. doi:10.1124/mol.105.018275. PMID 16258073.
Simpson RE, Ciruela A, Cooper DM (Jun 2006). "The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8". The Journal of Biological Chemistry 281 (25): 17379–89. doi:10.1074/jbc.M510992200. PMID 16613843.
Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M (Jul 2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMC 1986749. PMID 17586501.

Phosphorus-oxygen lyases (EC 4.6)

4.6.1

Adenylate cyclase
(4.6.1.1)

intracellular	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10

extracellular	Extracellular adenylate cyclase

Guanylate cyclase
(4.6.1.2)

soluble guanylyl cyclase	GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3

guanylate cyclase-coupled receptor	GUCY2C GUCY2D ANP (NPR1 NPR2)

Other

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Sunday, February 07, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

ADCY8

Function

References

Further reading