ACSS2
| Acyl-CoA synthetase short-chain family member 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ACSS2 ; ACAS2; ACECS; ACS; ACSA; dJ1161H23.1 | ||||||||||||
| External IDs | OMIM: 605832 MGI: 1890410 HomoloGene: 6469 GeneCards: ACSS2 Gene | ||||||||||||
| EC number | 6.2.1.1 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55902 | 60525 | |||||||||||
| Ensembl | ENSG00000131069 | ENSMUSG00000027605 | |||||||||||
| UniProt | Q9NR19 | Q9QXG4 | |||||||||||
| RefSeq (mRNA) | NM_001076552 | NM_019811 | |||||||||||
| RefSeq (protein) | NP_001070020 | NP_062785 | |||||||||||
| Location (UCSC) |
Chr 20: 34.87 – 34.93 Mb |
Chr 2: 155.52 – 155.59 Mb | |||||||||||
| PubMed search | |||||||||||||
Acetyl-coenzyme A synthetase, cytoplasmic is an enzyme that in humans is encoded by the ACSS2 gene.[1][2]
Function
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Two transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ Luong A, Hannah VC, Brown MS, Goldstein JL (Aug 2000). "Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins". The Journal of Biological Chemistry 275 (34): 26458–66. doi:10.1074/jbc.M004160200. PMID 10843999.
- 1 2 "Entrez Gene: ACSS2 acyl-CoA synthetase short-chain family member 2".
Further reading
- Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E (Jul 2006). "Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2". Proceedings of the National Academy of Sciences of the United States of America 103 (27): 10224–9. doi:10.1073/pnas.0603968103. PMC 1502439. PMID 16788062.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
This article is issued from Wikipedia - version of the Saturday, July 25, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.