ACSL3

Acyl-CoA synthetase long-chain family member 3

Identifiers

ACSL3 ; ACS3; FACL3; PRO2194

External IDs

OMIM: 602371 MGI: 1921455 HomoloGene: 3278 GeneCards: ACSL3 Gene

6.2.1.3

Gene ontology
Molecular function	• long-chain fatty acid-CoA ligase activity • ATP binding • protein kinase binding • protein domain specific binding
Cellular component	• mitochondrial outer membrane • peroxisomal membrane • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • lipid particle • membrane • integral component of membrane • perinuclear region of cytoplasm
Biological process	• long-chain fatty acid metabolic process • fatty acid biosynthetic process • brain development • response to nutrient • response to organic cyclic compound • triglyceride biosynthetic process • very-low-density lipoprotein particle assembly • long-chain fatty-acyl-CoA biosynthetic process • positive regulation of Golgi to plasma membrane protein transport • cellular lipid metabolic process • small molecule metabolic process • long-chain fatty acid import • positive regulation of secretion • positive regulation of phosphatidylcholine biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
222.86 – 222.94 Mb

Chr 1:
78.66 – 78.71 Mb

PubMed search

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.^[1]

Function

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.^[1]

References

1 2 "Entrez Gene: ACSL3 acyl-CoA synthetase long-chain family member 3".

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Bronfman M, Inestrosa NC, Nervi FO, Leighton F (Dec 1984). "Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization". The Biochemical Journal 224 (3): 709–20. PMC 1144505. PMID 6240978.
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Fujino T, Kang MJ, Suzuki H, Iijima H, Yamamoto T (Jul 1996). "Molecular characterization and expression of rat acyl-CoA synthetase 3". The Journal of Biological Chemistry 271 (28): 16748–16752. doi:10.1074/jbc.271.28.16748. PMID 8663269.
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Qiao S, Tuohimaa P (Nov 2004). "Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells". FEBS Letters 577 (3): 451–454. doi:10.1016/j.febslet.2004.10.044. PMID 15556626.
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Zhou Y, Abidi P, Kim A, Chen W, Huang TT, Kraemer FB, Liu J (Oct 2007). "Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation". Arteriosclerosis, Thrombosis, and Vascular Biology 27 (10): 2198–2205. doi:10.1161/ATVBAHA.107.148429. PMID 17761945.

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ACSL3

Function

References

Further reading