Trans-cinnamate 4-monooxygenase

trans-cinnamate 4-monooxygenase
Identifiers
EC number 1.14.13.11
CAS number 9077-75-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a trans-cinnamate 4-monooxygenase (EC 1.14.13.11) is an enzyme that catalyzes the chemical reaction

trans-cinnamate + NADPH + H+ + O2 \rightleftharpoons 4-hydroxycinnamate + NADP+ + H2O

The 4 substrates of this enzyme are trans-cinnamate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxycinnamate, NADP+, and H2O. This enzyme participates in phenylalanine metabolism and phenylpropanoid biosynthesis. It employs one cofactor, heme.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.

Nomenclature

The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:

  • cinnamic acid 4-hydroxylase,
  • oxygenase, cinnamate 4-mono-,
  • CA4H,
  • cytochrome P450 cinnamate 4-hydroxylase,
  • cinnamate 4-hydroxylase,
  • cinnamate 4-monooxygenase,
  • cinnamate hydroxylase,
  • cinnamic 4-hydroxylase,
  • cinnamic acid 4-monooxygenase,
  • cinnamic acid p-hydroxylase,
  • hydroxylase, cinnamate 4-,
  • t-cinnamic acid hydroxylase,
  • trans-cinnamate 4-hydroxylase, and
  • trans-cinnamic acid 4-hydroxylase.

References

    Further reading

    This article is issued from Wikipedia - version of the Thursday, December 31, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.