4-chlorobenzoate—CoA ligase

4-chlorobenzoate-CoA ligase
Identifiers
EC number 6.2.1.33
CAS number 141583-20-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-chlorobenzoate—CoA ligase (EC 6.2.1.33) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + CoA + ATP \rightleftharpoons 4-chlorobenzoyl-CoA + AMP + diphosphate

The 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, magnesium.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5D and 1T5H.

References

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