Methylcholanthrene
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| Names | |
|---|---|
| Other names
20–Methylcholanthrene | |
| Identifiers | |
56-49-5  | |
| Abbreviations | 3-MC 20-MC |
| ChEBI | CHEBI:34342  |
| ChEMBL | ChEMBL40583 |
| ChemSpider | 264105 |
| Jmol interactive 3D | Image |
| PubChem | 299006 |
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| Properties | |
| C21H16 | |
| Molar mass | 268.35 g/mol |
| Appearance | Yellow solid |
| Melting point | 180 °C (356 °F; 453 K) |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Methylcholanthrene (MCA) is a highly carcinogenic polycyclic aromatic hydrocarbon produced by burning organic compounds at very high temperatures. It is a yellow solid with a melting point around 180 °C. Methylcholanthrene is used in laboratory studies of chemical carcinogenesis. It is an alkylated derivative of benz[a]anthracene and has a similar UV spectrum. The most common isomer is 3-methylcholanthrene, although the methyl group can occur in other places.
3-Methylcholanthrene, a known carcinogen which builds up in the prostate due to cholesterol breakdown, is implicated in prostate cancer. It "readily produces" primary sarcomas in mice.[1]
References
- ↑ Donald C. Malins, Katie M. Anderson, Naomi K. Gilman, Virginia M. Green, Edward A. Barker and Karl Erik Hellström (2004). "Development of a Cancer DNA Phenotype Prior to Tumor Formation". PNAS 101 (29): 10721–10725. doi:10.1073/pnas.0403888101. JSTOR 3372726. PMC 490001. PMID 15249662.
External links
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