3-Methoxymorphinan
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| Clinical data | |
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| Legal status |
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| Identifiers | |
| CAS Number |
1531-25-5  |
| PubChem | CID 5484286 |
| ChemSpider |
10207434  |
| Chemical data | |
| Formula | C17H23NO |
| Molar mass | 257.37 g/mol |
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| (what is this?) (verify) | |
3-Methoxymorphinan is a dextromethorphan metabolite that has been shown to produce local anesthetic effects.[1] It is metabolized in the liver by the enzyme CYP3A4.[2]
References
- ↑ Hou, Chia-Hui; Tzeng, Jann-Inn; Chen, Yu-Wen; Lin, Ching-Nan; Lin, Mao-Tsun; Tu, Chieh-Hsien; Wang, Jhi-Joung (2006). "Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats". European Journal of Pharmacology 544 (1–3): 10–6. doi:10.1016/j.ejphar.2006.06.013. PMID 16844109.
- ↑ Min, David I.; Ku, Yi-Min; Vichiendilokkul, Aungkana; Fleckenstein, Lawrence L. (1999). "A Urine Metabolic Ratio of Dextromethorphan and 3-Methoxymorphinan as a Probe for CYP3A Activity and Prediction of Cyclosporine Clearance in Healthy Volunteers". Pharmacotherapy 19 (6): 753–9. doi:10.1592/phco.19.9.753.31536. PMID 10391422.
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