3-HO-PCP
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| Systematic (IUPAC) name | |
|---|---|
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3-[1-(Piperidin-1-yl)cyclohexyl]phenol | |
| Clinical data | |
| Legal status |
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| Identifiers | |
| CAS Number | 79787-43-2(freebase) 79295-51-5 (hydrochloride) |
| PubChem | CID 133277 |
| ChemSpider | 117583 |
| Chemical data | |
| Formula | C17H25NO |
| Molar mass | 259.39 |
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3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative anesthetic that has been sold online as a designer drug.[1] 3-HO-PCP binds to the NMDA and opioid receptors.[2][3][4][5][6][7][8][9]
On October 18, 2012 the Advisory Council on the Misuse of Drugs in the United Kingdom released a reportabout methoxetamine, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of MXE should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-HO-PCP.[10]
See also
References
- ↑ Morris, H.; Wallach, J. (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6: 614–632. doi:10.1002/dta.1620. PMID 24678061.
- ↑ Yossef Itzhak (1986). "High and low affinity psychotomimetic opioid binding sites: characterization by a novel 3H-PCP-analog." (PDF). NIDA Research Morograph 75: 173–176. PMID 2828967.
- ↑ J. M. Kamenka, B. Chiche, R. Goudal, P. Geneste, J. Vignon, J. P. Vincent, M. Lazdunski (April 1982). "Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl)piperidine derivatives". Journal of Medicinal Chemistry 25 (4): 431–435. doi:10.1021/jm00346a019. PMID 6279847.
- ↑ Yossef Itzhak, Asher Kalir, Yosef Sarne (July 1981). "On the opioid nature of phencyclidine and its 3-hydroxy derivative". European Journal of Pharmacology 73 (2–3): 229–233. doi:10.1016/0014-2999(81)90097-2. PMID 6273187.
- ↑ Nicole Johnson, Yossef Itzhak, Gavril W. Pasternak (June 1984). "Interaction of two phencyclidine opiate-like derivatives with 3H-opioid binding sites". European Journal of Pharmacology 101 (3–4): 281–284. doi:10.1016/0014-2999(84)90171-7. PMID 6088255.
- ↑ Yossef Itzhak (1988). "Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites". Life Sciences 42 (7): 745–752. doi:10.1016/0024-3205(88)90646-7. PMID 2893238.
- ↑ Yossef Itzhak (April 1987). "[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity". European Journal of Pharmacology 136 (2): 231–234. doi:10.1016/0014-2999(87)90715-1. PMID 3036548.
- ↑ Yossef Itzhak, Mabda Khouri (February 1988). "Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions". Neuroscience Letters 85 (1): 147–152. doi:10.1016/0304-3940(88)90445-4. PMID 2834673.
- ↑ Toshihito Suzuki, Toshifumi Yamamoto, Takafumi Hori, Shuzo Abe, Takashi Moroji, Hiroyasu Shiraishi, Takehiko Ito, Ing Kang Ho (1995). "Quantitative autoradiographic localization of [3H]3-OH-PCP (1-(1(3-Hydroxyphenyl)cyclohexyl)piperidine) binding sites in rat brain". Brain Research Bulletin 37 (4): 431–435. doi:10.1016/0361-9230(95)00005-4. PMID 7620917.
- ↑ "(ACMD) Methoxetamine Report (2012)" (PDF). UK Home Office. 2012-10-18. p. 14. Retrieved 2015-06-24.
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