23S rRNA (adenine2503-C2)-methyltransferase

23S rRNA (adenine2503-C2)-methyltransferase
Identifiers
EC number 2.1.1.192
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192, RlmN, YfgB, Cfr) is an enzyme with system name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2)-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA \rightleftharpoons S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

23S rRNA (adenine2503-C2)-methyltransferase contains an [4Fe-4S] cluster.

References

  1. Toh, S.M., Xiong, L., Bae, T. and Mankin, A.S. (2008). "The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA". RNA 14 (1): 98–106. doi:10.1261/rna.814408. PMC 2151032. PMID 18025251.
  2. Yan, F., LaMarre, J.M., Röhrich, R., Wiesner, J., Jomaa, H., Mankin, A.S., Fujimori, D.G. (2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". J. Am. Chem. Soc. 132 (11): 3953–3964. doi:10.1021/ja910850y. PMC 2859901. PMID 20184321.
  3. Yan, F. and Fujimori, D.G. (2011). "RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift". Proc. Natl. Acad. Sci. USA 108 (10): 3930–3934. doi:10.1073/pnas.1017781108. PMC 3054002. PMID 21368151.
  4. Grove, T.L., Benner, J.S., Radle, M.I., Ahlum, J.H., Landgraf, B.J., Krebs, C. and Booker, S.J. (2011). "A radically different mechanism for S-adenosylmethionine-dependent methyltransferases". Science 332 (6029): 604–607. doi:10.1126/science.1200877. PMID 21415317.
  5. Boal, A.K., Grove, T.L., McLaughlin, M.I., Yennawar, N.H., Booker, S.J. and Rosenzweig, A.C. (2011). "Structural basis for methyl transfer by a radical SAM enzyme". Science 332 (6033): 544–545. doi:10.1126/science.1205358. PMID 21527678.

External links

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