L-AP4
 | |
| Systematic (IUPAC) name | |
|---|---|
|
(2S)-2-amino-4-phosphonobutanoic acid | |
| Identifiers | |
| CAS Number |
23052-81-5  |
| PubChem | CID 179394 |
| IUPHAR/BPS | 1410 |
| ChemSpider |
156157  |
| Chemical data | |
| Formula | C4H10NO5P |
| Molar mass | 183.099 g/mol |
| |
| |
| (what is this?) (verify) | |
L-2-amino-4-phosphonobutyric acid (or L-AP4) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]
References
- ↑ Thomsen C (1997). "The L-AP4 receptor". General pharmacology 29 (2): 151–8. doi:10.1016/S0306-3623(96)00417-X. PMID 9251893.
- ↑ Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". Journal of Neuroscience 27 (25): 6701–11. doi:10.1523/JNEUROSCI.0299-07.2007. PMID 17581957.
- ↑ MacInnes N, Duty S (2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European Journal of Pharmacology 580 (1–2): 95–9. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348.
- ↑ Zhang HM, Chen SR, Pan HL (2009). "Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain". Neuroscience 158 (2): 875–84. doi:10.1016/j.neuroscience.2008.10.042. PMC 2649787. PMID 19017536.
- ↑ MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A, Hamed A, Wisłowska-Stanek A, Płaźnik A (2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain Research 1282: 20–7. doi:10.1016/j.brainres.2009.05.049. PMID 19481536.
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