Vertigo

This article is about the medical condition. For other uses, see Vertigo (disambiguation).
Not to be confused with acrophobia, an extreme or irrational fear of heights.
Vertigo

Horizontal nystagmus, a sign which can accompany vertigo.
Classification and external resources
Pronunciation /ˈvɜːrtᵻɡoʊ/
Specialty Otorhinolaryngology
ICD-10 H81, R42
ICD-9-CM 438.85, 780.4
DiseasesDB 29286
eMedicine article/1159385
Patient UK Vertigo
MeSH D014717

Vertigo is when a person feels as if they or the objects around them are moving when they are not.[1] Often it feels like a spinning or swaying movement.[1][2] This may be associated with nausea, vomiting, sweating, or difficulties walking. It is typically worsened when the head is moved. Vertigo is the most common type of dizziness.[2]

The most common diseases that result in vertigo are benign paroxysmal positional vertigo, Ménière's disease, and labyrinthitis.[1][2] Less common causes include stroke, brain tumors, brain injury, multiple sclerosis, and migraines.[2] Physiologic vertigo may occur following being exposed to motion for a prolonged period such as when on a ship or simply following spinning with the eyes closed.[3][4] Other causes may include toxin exposures such as to carbon monoxide, alcohol, or aspirin.[5] Vertigo is a problem in a part of the vestibular system. Other causes of dizziness include presyncope, disequilibrium, and non-specific dizziness.[2]

Benign paroxysmal positional vertigo is more likely in someone who gets repeated episodes of vertigo with movement and are otherwise normal between these episodes.[6] The episodes of vertigo should last less than one minute.[2] The Dix-Hallpike test typically produces a period of rapid eye movements known as nystagmus in this condition.[1] In Ménière's disease there is often ringing in the ears, hearing loss, and the attacks of vertigo last more than twenty minutes. In labyrinthitis the onset of vertigo is sudden and the nystagmus occurs without movement.[6] In this condition vertigo can last for days.[2] More severe causes should also be considered.[6] This is especially true if other problems such as weakness, headache, double vision, or numbness occur.[2]

Dizziness affects approximately 20%-40% of people at some point in time while about 7.5%-10% have vertigo.[7] About 5% have vertigo in a given year. It becomes more common with age and affects women two to three times more often than men. Vertigo accounts for about 2-3% of emergency department visits in the developed world.[8]

Classification

Vertigo is classified into either peripheral or central depending on the location of the dysfunction of the vestibular pathway,[9] although it can also be caused by psychological factors.[10]

Vertigo can also be classified into objective, subjective, and pseudovertigo. Objective vertigo describes when the person has the sensation that stationary objects in the environment are moving.[11][12] Subjective vertigo refers to when the person feels as if they are moving.[11][12] The third type is known as pseudovertigo, an intensive sensation of rotation inside the person's head. While this classification appears in textbooks, it has little to do with the pathophysiology or treatment of vertigo.[13]

Peripheral

Vertigo that is caused by problems with the inner ear or vestibular system, which is composed of the semicircular canals, the vestibule (utricle and saccule), and the vestibular nerve is called "peripheral", "otologic" or "vestibular" vertigo.[11][14] The most common cause is benign paroxysmal positional vertigo (BPPV), which accounts for 32% of all peripheral vertigo.[14] Other causes include Ménière's disease (12%), superior canal dehiscence syndrome, labyrinthitis, and visual vertigo.[14][15] Any cause of inflammation such as common cold, influenza, and bacterial infections may cause transient vertigo if it involves the inner ear, as may chemical insults (e.g., aminoglycosides)[16] or physical trauma (e.g., skull fractures). Motion sickness is sometimes classified as a cause of peripheral vertigo.

Patients with peripheral vertigo typically present with mild to moderate imbalance, nausea, vomiting, hearing loss, tinnitus, fullness, and pain in the ear.[14] In addition, lesions of the internal auditory canal may be associated with facial weakness on the same side.[14] Due to a rapid compensation process, acute vertigo as a result of a peripheral lesion tends to improve in a short period of time (days to weeks).[14]

Central

Vertigo that arises from injury to the balance centers of the central nervous system (CNS), often from a lesion in the brainstem or cerebellum,[6][11][17] is called "central" vertigo and is generally associated with less prominent movement illusion and nausea than vertigo of peripheral origin.[18] Central vertigo may have accompanying neurologic deficits (such as slurred speech and double vision), and pathologic nystagmus (which is pure vertical/torsional).[14][18] Central pathology can cause disequilibrium which is the sensation of being off balance. The balance disorder associated with central lesions causing vertigo is often so severe that many patients are unable to stand or walk.[14]

A number of conditions that involve the central nervous system may lead to vertigo including: lesions caused by infarctions or hemorrhage, tumors present in the cerebellopontine angle such as a vestibular schwannoma or cerebellar tumors,[6][9] epilepsy,[19] cervical spine disorders such as cervical spondylosis,[9] degenerative ataxia disorders,[6] migraine headaches,[6] lateral medullary syndrome, Chiari malformation,[6] multiple sclerosis,[6] parkinsonism, as well as cerebral dysfunction.[14] Central vertigo may not improve or may do so more slowly than vertigo caused by disturbance to peripheral structures.[14]

Signs and symptoms

Vertigo is a sensation of spinning while stationary.[20] It is commonly associated with nausea or vomiting,[19] unsteadiness (postural instability),[17] falls,[21] changes to a person's thoughts, and difficulties in walking.[22] Recurrent episodes in those with vertigo are common and frequently impair the quality of life.[8] Blurred vision, difficulty in speaking, a lowered level of consciousness, and hearing loss may also occur. The signs and symptoms of vertigo can present as a persistent (insidious) onset or an episodic (sudden) onset.[23]

Persistent onset vertigo is characterized by symptoms lasting for longer than one day[23] and is caused by degenerative changes that affect balance as people age. Naturally, the nerve conduction slows with aging and a decreased vibratory sensation is common.[24] Additionally, there is a degeneration of the ampulla and otolith organs with an increase in age.[25] Persistent onset is commonly paired with central vertigo signs and systems.[23]

The characteristics of an episodic onset vertigo is indicated by symptoms lasting for a smaller, more memorable amount of time, typically lasting for only seconds to minutes.[23] Typically, episodic vertigo is correlated with peripheral symptoms and can be the result of but not limited to diabetic neuropathy or autoimmune disease.

Motion sickness

Motion sickness is one of the most prominent symptoms of vertigo and develops most often in persons with inner ear problems. The feeling of dizziness and lightheadedness is often accompanied by nystagmus (an involuntary movement of the eye characterized by a smooth pursuit eye movement followed by a rapid saccade in the opposite direction of the smooth pursuit eye movement). During a single episode of vertigo, this action will occur repeatedly. Symptoms can fade while sitting still with the eyes closed.

Diagnostic approach

Tests for vertigo often attempt to elicit nystagmus and to differentiate vertigo from other causes of dizziness such as presyncope, hyperventilation syndrome, disequilibrium, or psychiatric causes of lightheadedness.[1] Tests of vestibular system (balance) function include: electronystagmography (ENG),[1] Dix-Hallpike maneuver,[1] rotation tests, head-thrust test,[6] caloric reflex test,[6][26] and computerized dynamic posturography (CDP).[27] The HINTS test, which is a combination of three physical exam tests that may be performed by physicians at the bedside has been deemed helpful in differentiating between central and peripheral causes of vertigo. The HINTS test involves: the horizontal head impulse test, observation of nystagmus on primary gaze, and the test of skew.[28] CT scans or MRIs are sometimes used by physicians when diagnosing vertigo.[19]

Tests of auditory system (hearing) function include pure tone audiometry, speech audiometry, acoustic reflex, electrocochleography (ECoG), otoacoustic emissions(OAE), and the auditory brainstem response test.[27]

A number of specific conditions can cause vertigo. In the elderly, however, the condition is often multifactorial.[8]

Peripheral causes

Benign paroxysmal positional vertigo

Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder[7] and occurs when loose calcium carbonate debris has broken off of the otoconial membrane and enters a semicircular canal thereby creating the sensation of motion.[1][6] Patients with BPPV may experience brief periods of vertigo, usually under a minute,[6] which occur with change in position.[29] This is the most common etiology of vertigo.[8] It occurs in 0.6% of the population yearly with 10% having an attack during their lifetime.[8] It is believed to be due to a mechanical malfunction of the inner ear.[8] BPPV may be diagnosed with the Dix-Hallpike test and can be effectively treated with repositioning movements such as the Epley maneuver.[8][29][30][31]

Ménière's disease

Ménière's disease is a vestibular disorder of unknown origin, but is thought to be caused by an increase in the amount of endolymphatic fluid present in the inner ear (endolymphatic hydrops).[1] However, this idea has not been directly confirmed with histopathologic studies but electrophysiologic studies have been suggestive of this mechanism.[32] Ménière's disease frequently presents with recurrent, spontaneous attacks of severe vertigo in combination with ringing in the ears (tinnitus), a feeling of pressure or fullness in the ear (aural fullness), severe nausea or vomiting, imbalance, and hearing loss.[6][23][32] As the disease worsens, hearing loss will progress.

Labyrinthitis

Labyrinthitis presents with severe vertigo[8] with associated nausea, vomiting, and generalized imbalance and is believed to be caused by a viral infection of the inner ear though several theories have been put forward and the etiology remains uncertain.[6][33] Individuals with vestibular neuritis do not typically have auditory symptoms but may experience a sensation of aural fullness or tinnitus.[33] Persisting balance problems may remain in 30% of people affected.[8]

Vestibular migraine

Vestibular migraine is the association of vertigo and migraines and is one of the most common causes of recurrent, spontaneous episodes of vertigo.[7][8] The etiology of vestibular migraines is currently unclear;[7] however, one hypothesized cause is that the stimulation of the trigeminal nerve leads to nystagmus in individuals suffering from migraines.[1] Other suggested causes of vestibular migraines include the following: unilateral neuronal instability of the vestibular nerve, idiopathic asymmetric activation of the vestibular nuclei in the brainstem, and vasospasm of the blood vessels supplying the labyrinth or central vestibular pathways resulting in ischemia to these structures.[19] Vestibular migraines are estimated to affect 1-3% of the general population[1][8] and may affect 10% of migraine patients.[1] Additionally, vestibular migraines tend to occur more often in women and rarely affect individuals after the sixth decade of life.[7]

Central causes

Stroke

A stroke (either ischemic or hemorrhagic) involving the posterior fossa is a cause of central vertigo.[28] Risk factors for a stroke as a cause of vertigo include increasing age and known vascular risk factors. Presentation may more often involve headache or neck pain, additionally, those who have had multiple episodes of dizziness in the months leading up to presentation are suggestive of stroke with prodromal TIAs.[28] The HINTS exam as well as imaging studies of the brain (CT, CT angiogram, and/or MRI) are helpful in diagnosis of posterior fossa stroke.[28]

Pathophysiology

The neurochemistry of vertigo includes six primary neurotransmitters that have been identified between the three-neuron arc[34] that drives the vestibulo-ocular reflex (VOR). Glutamate maintains the resting discharge of the central vestibular neurons, and may modulate synaptic transmission in all three neurons of the VOR arc. Acetylcholine appears to function as an excitatory neurotransmitter in both the peripheral and central synapses. Gamma-Aminobutyric acid (GABA) is thought to be inhibitory for the commissures of the medial vestibular nucleus, the connections between the cerebellar Purkinje cells, and the lateral vestibular nucleus, and the vertical VOR.

Three other neurotransmitters work centrally. Dopamine may accelerate vestibular compensation. Norepinephrine modulates the intensity of central reactions to vestibular stimulation and facilitates compensation. Histamine is present only centrally, but its role is unclear. Dopamine, histamine, serotonin, and acetylcholine are neurotransmitters thought to produce vomiting.[6] It is known that centrally acting antihistamines modulate the symptoms of acute symptomatic vertigo.[35]

Management

Definitive treatment depends on the underlying cause of vertigo.[6] Ménière's disease patients have a variety of treatment options to consider when receiving treatment for vertigo and tinnitus including: a low-salt diet and intratympanic injections of the antibiotic gentamicin or surgical measures such as a shunt or ablation of the labyrinth in refractory cases.[36] Common drug treatment options for vertigo may include the following:[37]

Etymology

Vertigo is from the Latin word vertō which means "a whirling or spinning movement".[40]

Media treatment

In the Alfred Hitchcock film Vertigo, the hero, played by James Stewart, has to resign from the police force after an incident which causes him to develop both acrophobia and vertigo. Early on in the film he faints while climbing a stepladder. There are numerous references throughout the film to fear of heights and falling, The dolly zoom camera effect, also called the "vertigo effect", was first used in this film.

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 Post, RE; Dickerson, LM (2010). "Dizziness: a diagnostic approach". American Family Physician 82 (4): 361–369. PMID 20704166.
  2. 1 2 3 4 5 6 7 8 Hogue, JD (June 2015). "Office Evaluation of Dizziness.". Primary care 42 (2): 249–258. doi:10.1016/j.pop.2015.01.004. PMID 25979586.
  3. ↑ Falvo, Donna R. (2014). Medical and psychosocial aspects of chronic illness and disability (5 ed.). Burlington, MA: Jones & Bartlett Learning. p. 273. ISBN 9781449694425.
  4. ↑ Wardlaw, Joanna M. (2008). Clinical neurology. London: Manson. p. 107. ISBN 9781840765182.
  5. ↑ Goebel, Joel A. (2008). Practical management of the dizzy patient (2nd ed.). Philadelphia: Lippincott Williams & Wilkins. p. 97. ISBN 9780781765626.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 Kerber, KA (2009). "Vertigo and dizziness in the emergency department". Emergency medicine clinics of North America 27 (1): 39–50. doi:10.1016/j.emc.2008.09.002. PMC 2676794. PMID 19218018.
  7. 1 2 3 4 5 von Brevern, M; Neuhauser, H (2011). "Epidemiological evidence for a link between vertigo & migraine". Journal of vestibular research: equilibrium & orientation 21 (6): 299–304. doi:10.3233/VES-2011-0423. PMID 22348934.
  8. 1 2 3 4 5 6 7 8 9 10 11 Neuhauser HK, Lempert T (November 2009). "Vertigo: epidemiologic aspects". Semin Neurol 29 (5): 473–81. doi:10.1055/s-0029-1241043. PMID 19834858.
  9. 1 2 3 Wippold 2nd, FJ; Turski, PA (2009). "Vertigo and hearing loss". AJNR. American journal of neuroradiology 30 (8): 1623–1625. PMID 19749077.
  10. ↑ "Chapter 14: Evaluation of the Dizzy Patient". Retrieved 2009-08-06.
  11. 1 2 3 4 U.S. National Library of Medicine (2011). "Vertigo-associated disorders". National Institutes of Health. Retrieved 2 January 2013.
  12. 1 2 Berkow R., ed. (1992). The Merck manual of diagnostics and therapy. Rahway: Merck & Co Inc. p. 2844.
  13. ↑ Ropper, AH; Brown RH (2005). Adams and Victor’s Principles of Neurology (eighth ed.). NY, Chicago, San Francisco. p. 1398.
  14. 1 2 3 4 5 6 7 8 9 10 Karatas, M (2008). "Central Vertigo and Dizziness". The Neurologist 14 (6): 355–364. doi:10.1097/NRL.0b013e31817533a3. PMID 19008741.
  15. ↑ Guerraz, M.; Yardley, L; Bertholon, P; Pollak, L; Rudge, P; Gresty, MA; Bronstein, AM (2001). "Visual vertigo: symptom assessment, spatial orientation and postural control". Brain 124 (8): 1646–1656. doi:10.1093/brain/124.8.1646. PMID 11459755.
  16. ↑ Xie, J; Talaska, AE; Schacht, J (2011). "New developments in aminoglycoside therapy and ototoxicity". Hearing research 281 (1–2): 28–37. doi:10.1016/j.heares.2011.05.008. PMC 3169717. PMID 21640178.
  17. 1 2 Jahn, K; Dieterich, M (December 2011). "Recent advances in the diagnosis and treatment of balance disorders". Journal of neurology 258 (12): 2305–2308. doi:10.1007/s00415-011-6286-4. PMID 22037955.
  18. 1 2 Dieterich, Marianne (2007). "Central vestibular disorders". Journal of Neurology 254 (5): 559–568. doi:10.1007/s00415-006-0340-7. PMID 17417688.
  19. 1 2 3 4 Taylor, J; Goodkin, HP (2011). "Dizziness and vertigo in the adolescent". Otolaryngologic Clinics of North America 44 (2): 309–321. doi:10.1016/j.otc.2011.01.004. PMID 21474006.
  20. ↑ "Vertigo: Dizziness and Vertigo: Merck Manual Home Edition".
  21. ↑ Vieira, ER; Freund-Heritage, R; Da Costa, BR (September 2011). "Risk factors for geriatric patient falls in rehabilitation hospital settings: a systematic review". Clinical rehabilitation 25 (9): 788–799. doi:10.1177/0269215511400639. PMID 21504956.
  22. ↑ Ricci, NA; Aratani, MC; Doná, F; MacEdo, C; Caovilla, HH; Ganança, FF (2010). "A systematic review about the effects of the vestibular rehabilitation of middle-age and older adults". Revista brasileira de fisioterapia 14 (5): 361–371. doi:10.1590/S1413-35552010000500003. PMID 21180862.
  23. 1 2 3 4 5 Strupp, M; Thurtell, MJ; Shaikh, AG; Brandt, T; Zee, DS; Leigh, RJ (July 2011). "Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus". Journal of neurology 258 (7): 1207–1222. doi:10.1007/s00415-011-5999-8. PMC 3132281. PMID 21461686.
  24. ↑ Kaneko, A; Asai, N; Kanda, T (2005). "The influence of age on pressure perception of static and moving two-point discrimination in normal subjects". Journal of hand therapy: official journal of the American Society of Hand Therapists 18 (4): 421–424. doi:10.1197/j.jht.2005.09.010. PMID 16271689.
  25. ↑ Kutz Jr, JW (September 2010). "The dizzy patient". The Medical clinics of North America 94 (5): 989–1002. doi:10.1016/j.mcna.2010.05.011. PMID 20736108.
  26. ↑ "Core Curriculum: Inner Ear Disease —Vertigo". Baylor College of Medicine. 23 January 2006. Archived from the original on 2007-06-30. Retrieved 19 September 2007.
  27. 1 2 "Diagnosis: How are vestibular disorders diagnosed?". Vestibular Disorders Association. 2013. Retrieved 9 January 2013.
  28. 1 2 3 4 Tarnutzer, Alexander A.; Berkowitz, Aaron L.; Robinson, Karen A.; Hsieh, Yu-Hsiang; Newman-Toker, David E. (2011-06-14). "Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome". Canadian Medical Association Journal 183 (9): E571–E592. doi:10.1503/cmaj.100174. ISSN 0820-3946. PMC 3114934. PMID 21576300.
  29. 1 2 MedlinePlus (2011). "Benign positional vertigo". U.S. National Institutes of Health. Retrieved 2 January 2013.
  30. ↑ Alvarenga, GA; Barbosa, MA; Porto, CC (2011). "Benign paroxysmal positional vertigo without nystagmus: diagnosis and treatment". Brazilian journal of otorhinolaryngology 77 (6): 799–804. doi:10.1590/S1808-86942011000600018. PMID 22183288.
  31. ↑ Prim-Espada, MP; De Diego-Sastre, JI; Pérez-Fernández, E (June 2010). "[Meta-analysis on the efficacy of Epley's manoeuvre in benign paroxysmal positional vertigo]" (PDF). Neurologia 25 (5): 295–299. doi:10.1016/j.nrl.2010.01.004. PMID 20643039.
  32. 1 2 Semaan, MT; Megerian, CA (April 2011). "Ménière's disease: a challenging and relentless disorder". Otolaryngologic Clinics of North America 44 (2): 383–403. doi:10.1016/j.otc.2011.01.010. PMID 21474013.
  33. 1 2 Goddard, JC; Fayad, JN (2011). "Vestibular Neuritis". Otolaryngologic Clinics of North America 44 (2): 361–365. doi:10.1016/j.otc.2011.01.007. PMID 21474010.
  34. ↑ Angelaki, DE (July 2004). "Eyes on target: what neurons must do for the vestibuloocular reflex during linear motion". Journal of Neurophysiology 92 (1): 20–35. doi:10.1152/jn.00047.2004. PMID 15212435.
  35. ↑ Kuo, CH; Pang, L; Chang, R (June 2008). "Vertigo-part 2-management in general practice" (PDF). Australian family physician 37 (6): 409–413. PMID 18523693.
  36. ↑ Huon, LK; Fang, TY; Wang, PC (July 2012). "Outcomes of intratympanic gentamicin injection to treat Ménière's disease". Otology & Neurotology 33 (5): 706–714. doi:10.1097/MAO.0b013e318259b3b1. PMID 22699980.
  37. ↑ Huppert, D; Strupp, M; Mückter, H; Brandt, T (March 2011). "Which medication do I need to manage dizzy patients?". Acta oto-laryngologica 131 (3): 228–241. doi:10.3109/00016489.2010.531052. PMID 21142898.
  38. ↑ Fauci, Anthony S.; Daniel L. Kasper; Dan L. Longo; Eugene Braunwald; Stephen L. Hauser; J. Larry Jameson (2008). Chapter 22. Dizziness and Vertigo Harrison's Principles of Internal Medicine (17th ed.). New York: McGraw-Hill. ISBN 978-0-07-147691-1.
  39. ↑ Khilnani, AK; Thaddanee, R; Khilnani, G (July 2013). "Anti vertigo drugs-Revisited". National Journal of Integrated Research in Medicine 4 (4): 118–28.
  40. ↑ "Definition of vertigo". Merriam-Webster Online Dictionary. Retrieved 2007-09-19.
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