Zucapsaicin

Zucapsaicin

Systematic (IUPAC) name
(Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Clinical data
Trade names	Civanex
Routes of administration	Topical
Identifiers
CAS Registry Number	25775-90-0
ATC code	M02AB02
PubChem	CID 1548942
ChemSpider	1265956
UNII	15OX67P384
Synonyms	Civamide; (Z)-Capsaicin; cis-Capsaicin
Chemical data
Formula	C18H27NO3
Molecular mass	305.41188 g/mol
SMILES Oc1ccc(cc1OC)CNC(CCCC\C=C/C(C)C)=O
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6- Key:YKPUWZUDDOIDPM-VURMDHGXSA-N

Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).^[1]

Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis.^[2]

References