Zinc-activated ion channel

Zinc activated ligand-gated ion channel
Identifiers
SymbolsZACN ; L2; LGICZ; LGICZ1; ZAC; ZAC1
External IDsOMIM: 610935 HomoloGene: 52296 IUPHAR: 587 ChEMBL: 1628479 GeneCards: ZACN Gene
Orthologs
SpeciesHumanMouse
Entrez353174n/a
EnsemblENSG00000186919n/a
UniProtQ401N2n/a
RefSeq (mRNA)NM_180990n/a
RefSeq (protein)NP_851321n/a
Location (UCSC)Chr 17:
74.07 – 74.08 Mb		n/a
PubMed searchn/a

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[1]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[1][2] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[1]

References

  1. ↑ 1.0 1.1 1.2 Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
  2. ↑ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.