ZWINT

ZW10 interacting kinetochore protein

Identifiers

ZWINT ; HZwint-1; KNTC2AP; ZWINT1

External IDs

OMIM: 609177 MGI: 1289227 HomoloGene: 48496 GeneCards: ZWINT Gene

Gene ontology
Molecular function	• protein binding • protein N-terminus binding
Cellular component	• kinetochore • condensed chromosome kinetochore • nucleus • cytoplasm • cytosol • dendrite
Biological process	• mitotic sister chromatid segregation • mitotic cell cycle • cell cycle • spindle organization • mitotic cell cycle checkpoint • phosphatidylinositol-mediated signaling • establishment of localization in cell
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
58.12 – 58.12 Mb

Chr 10:
72.65 – 72.67 Mb

PubMed search

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.^[1]

Function

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

Interactions

ZWINT has been shown to interact with MIS12.^[2]^[3]

References

↑ 1.0 1.1 "Entrez Gene: ZWINT ZW10 interactor".
↑ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.

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Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Starr DA; Saffery R; Li Z et al. (2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". J. Cell. Sci. 113 (11): 1939–50. PMID 10806105.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Musio A; Mariani T; Montagna C et al. (2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.
Cheeseman IM; Niessen S; Anderson S et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Wang H; Hu X; Ding X et al. (2005). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". J. Biol. Chem. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Obuse C; Iwasaki O; Kiyomitsu T et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Le XF; Lammayot A; Gold D et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Kops GJ; Kim Y; Weaver BA et al. (2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". J. Cell Biol. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMC 1351127. PMID 15824131.
Lin YT, Chen Y, Wu G, Lee WH (2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327.

External links

ZWINT human gene location in the UCSC Genome Browser.
ZWINT human gene details in the UCSC Genome Browser.

ZWINT

Function

Interactions

References

Further reading

External links