ZNF41
Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.[1][2]
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known.[2]
References
Further reading
- Rosati M, Marino M, Franzè A et al. (1991). "Members of the zinc finger protein gene family sharing a conserved N-terminal module". Nucleic Acids Res. 19 (20): 5661–7. doi:10.1093/nar/19.20.5661. PMC 328972. PMID 1945843.
- Knight JC, Grimaldi G, Thiesen HJ et al. (1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
- Rosati M, Franzé A, Matarazzo MR, Grimaldi G (1999). "Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41". Cytogenet. Cell Genet. 85 (3–4): 291–6. doi:10.1159/000015315. PMID 10449920.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shoichet SA, Hoffmann K, Menzel C et al. (2004). "Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation". Am. J. Hum. Genet. 73 (6): 1341–54. doi:10.1086/380309. PMC 1180399. PMID 14628291.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| | (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| | subfamily 2 | |
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| | subfamily 3 | |
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| | subfamily 4 | |
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| | subfamily 5 | |
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| | subfamily 6 | |
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| | subfamily 0 | |
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| | (2.2) Other Cys4 | |
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| | (2.3) Cys2His2 | |
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| | (2.4) Cys6 | |
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| | (2.5) Alternating composition | |
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| | (2.6) WRKY | |
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| | | | | (4) β-Scaffold factors with minor groove contacts |
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| | | (0) Other transcription factors |
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| | see also transcription factor/coregulator deficiencies
Index of genetics |
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| | Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
- modification
- Translation
- ribosome
- modification
- nexins
- Proteins
- domains
- Structure
- primary
- secondary
- tertiary
- quaternary
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| | Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
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