ZFYVE26
| Zinc finger, FYVE domain containing 26 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ZFYVE26 ; FYVE-CENT; SPG15 | ||||||||||||
| External IDs | OMIM: 612012 HomoloGene: 9102 GeneCards: ZFYVE26 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23503 | 211978 | |||||||||||
| Ensembl | ENSG00000072121 | ENSMUSG00000066440 | |||||||||||
| UniProt | Q68DK2 | Q5DU37 | |||||||||||
| RefSeq (mRNA) | NM_015346 | NM_001008550 | |||||||||||
| RefSeq (protein) | NP_056161 | NP_001008550 | |||||||||||
| Location (UCSC) | Chr 14: 68.19 – 68.28 Mb | Chr 12: 79.23 – 79.3 Mb | |||||||||||
| PubMed search | |||||||||||||
Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene. [1]
Function
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008].
References
- ↑ "Entrez Gene: Zinc finger, FYVE domain containing 26". Retrieved 2014-02-23.
Further reading
- Elleuch, N; Bouslam, N; Hanein, S; Lossos, A; Hamri, A; Klebe, S; Meiner, V; Birouk, N; Lerer, I; Grid, D; Bacq, D; Tazir, M; Zelenika, D; Argov, Z; Durr, A; Yahyaoui, M; Benomar, A; Brice, A; Stevanin, G (2007). "Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families". Neurogenetics 8 (4): 307–15. doi:10.1007/s10048-007-0097-x. PMID 17661097.
- Boukhris, A; Stevanin, G; Feki, I; Denis, E; Elleuch, N; Miladi, M. I.; Truchetto, J; Denora, P; Belal, S; Mhiri, C; Brice, A (2008). "Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity". Archives of Neurology 65 (3): 393–402. doi:10.1001/archneur.65.3.393. PMID 18332254.
- Sagona, A. P.; Nezis, I. P.; Bache, K. G.; Haglund, K; Bakken, A. C.; Skotheim, R. I.; Stenmark, H (2011). "A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis". PLoS ONE 6 (3): e17086. doi:10.1371/journal.pone.0017086. PMC 3063775. PMID 21455500.
- Goizet, C; Boukhris, A; Maltete, D; Guyant-Maréchal, L; Truchetto, J; Mundwiller, E; Hanein, S; Jonveaux, P; Roelens, F; Loureiro, J; Godet, E; Forlani, S; Melki, J; Auer-Grumbach, M; Fernandez, J. C.; Martin-Hardy, P; Sibon, I; Sole, G; Orignac, I; Mhiri, C; Coutinho, P; Durr, A; Brice, A; Stevanin, G (2009). "SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum". Neurology 73 (14): 1111–9. doi:10.1212/WNL.0b013e3181bacf59. PMID 19805727.
- Sagona, A. P.; Nezis, I. P.; Pedersen, N. M.; Liestøl, K; Poulton, J; Rusten, T. E.; Skotheim, R. I.; Raiborg, C; Stenmark, H (2010). "Ptd Ins(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody". Nature Cell Biology 12 (4): 362–71. doi:10.1038/ncb2036. PMID 20208530.
- Schüle, R; Schlipf, N; Synofzik, M; Klebe, S; Klimpe, S; Hehr, U; Winner, B; Lindig, T; Dotzer, A; Riess, O; Winkler, J; Schöls, L; Bauer, P (2009). "Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia". Journal of Neurology, Neurosurgery & Psychiatry 80 (12): 1402–4. doi:10.1136/jnnp.2008.167528. PMID 19917823.
- Murmu, R. P.; Martin, E; Rastetter, A; Esteves, T; Muriel, M. P.; El Hachimi, K. H.; Denora, P. S.; Dauphin, A; Fernandez, J. C.; Duyckaerts, C; Brice, A; Darios, F; Stevanin, G (2011). "Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia". Molecular and Cellular Neuroscience 47 (3): 191–202. doi:10.1016/j.mcn.2011.04.004. PMID 21545838.
- Hanein, S; Martin, E; Boukhris, A; Byrne, P; Goizet, C; Hamri, A; Benomar, A; Lossos, A; Denora, P; Fernandez, J; Elleuch, N; Forlani, S; Durr, A; Feki, I; Hutchinson, M; Santorelli, F. M.; Mhiri, C; Brice, A; Stevanin, G (2008). "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome". The American Journal of Human Genetics 82 (4): 992–1002. doi:10.1016/j.ajhg.2008.03.004. PMC 2427184. PMID 18394578.
- Hughes, C. A.; Byrne, P. C.; Webb, S; McMonagle, P; Patterson, V; Hutchinson, M; Parfrey, N. A. (2001). "SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q". Neurology 56 (9): 1230–3. doi:10.1212/wnl.56.9.1230. PMID 11342696.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.