ZFYVE1
| Zinc finger, FYVE domain containing 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ZFYVE1 ; DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1 | ||||||||||||
| External IDs | OMIM: 605471 MGI: 3026685 HomoloGene: 10945 GeneCards: ZFYVE1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 53349 | 217695 | |||||||||||
| Ensembl | ENSG00000165861 | ENSMUSG00000042628 | |||||||||||
| UniProt | Q9HBF4 | Q810J8 | |||||||||||
| RefSeq (mRNA) | NM_001281734 | NM_183154 | |||||||||||
| RefSeq (protein) | NP_001268663 | NP_898977 | |||||||||||
| Location (UCSC) | Chr 14: 73.44 – 73.49 Mb | Chr 12: 83.55 – 83.6 Mb | |||||||||||
| PubMed search | |||||||||||||
Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.[1][2][3]
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution.
Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.[3]
References
- ↑ Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library". Gene 255 (2): 195–203. doi:10.1016/S0378-1119(00)00303-6. PMID 11024279.
- ↑ Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi". Biochem J 355 (Pt 1): 113–21. doi:10.1042/0264-6021:3550113. PMC 1221718. PMID 11256955.
- ↑ 3.0 3.1 "Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1".
Further reading
- Nagase T, Kikuno R, Nakayama M et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
- Ridley SH, Ktistakis N, Davidson K et al. (2002). "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.". J. Cell. Sci. 114 (Pt 22): 3991–4000. PMID 11739631.
- Krugmann S, Anderson KE, Ridley SH et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.". Mol. Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Heilig R, Eckenberg R, Petit JL et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.