ZFPM1

Zinc finger protein, FOG family member 1

PDB rendering based on 1srk.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2XU7

Identifiers

ZFPM1 ; FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A

External IDs

OMIM: 601950 MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1 Gene

Gene ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • RNA polymerase II transcription factor binding • RNA polymerase II activating transcription factor binding • DNA binding • protein binding • transcription factor binding • metal ion binding
Cellular component	• nucleoplasm • transcription factor complex • cytoplasm • transcriptional repressor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • T-helper cell lineage commitment • outflow tract morphogenesis • atrioventricular valve morphogenesis • mitral valve formation • tricuspid valve formation • transcription, DNA-templated • blood coagulation • regulation of definitive erythrocyte differentiation • erythrocyte differentiation • megakaryocyte differentiation • platelet formation • granulocyte differentiation • negative regulation of protein binding • regulation of chemokine production • embryonic hemopoiesis • megakaryocyte development • positive regulation of interferon-gamma biosynthetic process • negative regulation of interleukin-4 biosynthetic process • negative regulation of fat cell differentiation • cardiac muscle tissue morphogenesis • definitive erythrocyte differentiation • primitive erythrocyte differentiation • negative regulation of mast cell differentiation • ventricular septum morphogenesis • atrial septum morphogenesis • transcriptional activation by promoter-enhancer looping
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000179588

ENSMUSG00000049577

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
88.52 – 88.6 Mb

Chr 8:
122.28 – 122.34 Mb

PubMed search

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG1) is a protein that in humans is encoded by the ZFPM1 gene.^[1]

References

↑ "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Further reading

Tsang AP, Visvader JE, Turner CA et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.". Cell 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
Mehaffey MG, Newton AL, Gandhi MJ et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1.". Blood 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
Yu C, Niakan KK, Matsushita M et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.". Blood 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
Freson K, Thys C, Wittewrongel C et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Liew CK, Simpson RJ, Kwan AH et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
Vannucchi AM, Pancrazzi A, Guglielmelli P et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis.". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
Yang HY, Kim SH, Kim SH et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.

PDB gallery

1srk: Solution structure of the third zinc finger domain of FOG-1