ZBP1
| Z-DNA binding protein 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ZBP1 ; C20orf183; DAI; DLM-1; DLM1 | ||||||||||||
| External IDs | OMIM: 606750 MGI: 1927449 HomoloGene: 10972 GeneCards: ZBP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81030 | 58203 | |||||||||||
| Ensembl | ENSG00000124256 | ENSMUSG00000027514 | |||||||||||
| UniProt | Q9H171 | Q9QY24 | |||||||||||
| RefSeq (mRNA) | NM_001160417 | NM_001139519 | |||||||||||
| RefSeq (protein) | NP_001153889 | NP_001132991 | |||||||||||
| Location (UCSC) | Chr 20: 56.18 – 56.2 Mb | Chr 2: 173.21 – 173.22 Mb | |||||||||||
| PubMed search | |||||||||||||
Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in humans is encoded by the ZBP1 gene.[1][2]
ZBP1 is also an abbreviation for chicken or rat β-actin zipcode-binding protein 1, a homolog of the human insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1) and murine CRD-BP, the proteins involved in mRNA transport (RNA-binding proteins, RBPs).
Function
DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[2] ZBP1 recognizes DNA in the cytoplasm as an antiviral mechanism. Viral life cycles often include steps where DNA is exposed in the cytoplasm. DNA is normally contained in the nucleus of a cell, and therefore cells use proteins like ZBP1 as an indicator of a viral infection. Once ZBP1 is activated, it increases the production of antiviral cytokines such as interferon beta.[3]
Zipcode binding protein 1 (ZBP1) was shown to regulate dendritogenesis (dendrite formation) in hippocampal neurons.[4]
References
- ↑ Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (Feb 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Res 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111.
- ↑ 2.0 2.1 "Entrez Gene: ZBP1 Z-DNA binding protein 1".
- ↑ Rathinam VA, Fitzgerald KA (March 2011). "Innate immune sensing of DNA viruses". Virology 411 (2): 153–62. doi:10.1016/j.virol.2011.02.003. PMC 3070751. PMID 21334037.
- ↑ Perycz M, Urbanska AS, Krawczyk PS, Parobczak K, Jaworski J (April 2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons". J. Neurosci. 31 (14): 5271–85. doi:10.1523/JNEUROSCI.2387-10.2011. PMID 21471362.
Further reading
- Ha SC, Van Quyen D, Hwang HY et al. (2006). "Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA". Biochim. Biophys. Acta 1764 (2): 320–3. doi:10.1016/j.bbapap.2005.12.012. PMID 16448869.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. USA 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Schwartz T, Behlke J, Lowenhaupt K et al. (2001). "Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins". Nat. Struct. Biol. 8 (9): 761–5. doi:10.1038/nsb0901-761. PMID 11524677.
- Schwartz T, Rould MA, Lowenhaupt K et al. (1999). "Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA". Science 284 (5421): 1841–5. doi:10.1126/science.284.5421.1841. PMID 10364558.