YTHDC1
| YTH domain containing 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | YTHDC1 ; YT521; YT521-B | ||||||||||||
| External IDs | HomoloGene: 15796 GeneCards: YTHDC1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 91746 | 231386 | |||||||||||
| Ensembl | ENSG00000083896 | ENSMUSG00000035851 | |||||||||||
| UniProt | Q96MU7 | E9Q5K9 | |||||||||||
| RefSeq (mRNA) | NM_001031732 | NM_177680 | |||||||||||
| RefSeq (protein) | NP_001026902 | NP_808348 | |||||||||||
| Location (UCSC) | Chr 4: 69.18 – 69.22 Mb | Chr 5: 86.8 – 86.84 Mb | |||||||||||
| PubMed search | |||||||||||||
YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.[1][2][3]
Interactions
YTHDC1 has been shown to interact with:
References
- ↑ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
- ↑ 2.0 2.1 Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell 10 (11): 3909–26. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.
- ↑ "Entrez Gene: YTHDC1 YTH domain containing 1".
- ↑ 4.0 4.1 Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R et al. (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
- ↑ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I et al. (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
Further reading
- Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation.". Brain Res. Mol. Brain Res. 53 (1-2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
- Nayler O, Hartmann AM, Stamm S (2000). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment.". J. Cell Biol. 150 (5): 949–62. doi:10.1083/jcb.150.5.949. PMC 2175241. PMID 10973987.
- Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.". J. Biol. Chem. 276 (12): 8665–73. doi:10.1074/jbc.M006851200. PMID 11118435.
- Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
- Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I et al. (2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B.". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
- Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help)
- Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S (2005). "p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.". Mol. Cell. Neurosci. 27 (1): 8–21. doi:10.1016/j.mcn.2004.04.011. PMID 15345239.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. Vancouver style error (help)
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.