William Mayo
William Mayo is the name of:
- William B. Mayo (1860-1944), former chief engineer of the Ford Motor Company
- Two co-founders of the Mayo Clinic:
- William Worrall Mayo (1819-1911)
- William James Mayo (1861-1939)
- William Mayo (MP) (died 1723), English Member of Parliament
- William Mayo (civil engineer) (c.1685-1744), who laid out the city of Richmond, Virginia
- William Mayo (vicar), the vicar of Folke, Dorset, England in about 1845.
- William Leonidas Mayo, founder (in 1899) and first president of East Texas Normal College.