WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]
Function
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]
Interactions
WWP1 has been shown to interact with:
References
- ↑ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK et al. (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
- ↑ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J et al. (July 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
- ↑ 3.0 3.1 "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1".
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Conkright MD, Wani MA, Lingrel JB (August 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.
- ↑ Qin H, Pu HX, Li M, Ahmed S, Song J (Dec 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains.". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.
- Flasza M, Gorman P, Roylance R, Canfield AE, Baron M (2002). "Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.". Biochem. Biophys. Res. Commun. 290 (1): 431–7. doi:10.1006/bbrc.2001.6206. PMID 11779188.
- Galinier R, Gout E, Lortat-Jacob H, Wood J, Chroboczek J (2003). "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.". Biochemistry 41 (48): 14299–305. doi:10.1021/bi020125b. PMID 12450395.
- Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T et al. (2003). "Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.". Mol. Cell 11 (1): 249–59. doi:10.1016/S1097-2765(02)00774-8. PMID 12535537.
- Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K et al. (2004). "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).". Oncogene 23 (41): 6914–23. doi:10.1038/sj.onc.1207885. PMID 15221015.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J et al. (2005). "The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.". EMBO J. 23 (19): 3780–92. doi:10.1038/sj.emboj.7600398. PMC 522797. PMID 15359284.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen C, Sun X, Guo P, Dong XY, Sethi P, Cheng X et al. (2006). "Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.". J. Biol. Chem. 280 (50): 41553–61. doi:10.1074/jbc.M506183200. PMID 16223724.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. Vancouver style error (help)
- Flasza M, Nguyen Huu NS, Mazaleyrat S, Clémence S, Villemant C, Clarke R et al. (2006). "Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch.". Mol. Membr. Biol. 23 (3): 269–76. doi:10.1080/09687860600665010. PMID 16785210. Vancouver style error (help)
- Laine A, Ronai Z (2007). "Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1.". Oncogene 26 (10): 1477–83. doi:10.1038/sj.onc.1209924. PMC 2997392. PMID 16924229.
- Chen C, Sun X, Guo P, Dong XY, Sethi P, Zhou W et al. (2007). "Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer.". Oncogene 26 (16): 2386–94. doi:10.1038/sj.onc.1210021. PMID 17016436.
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