WNT2

Wingless-type MMTV integration site family member 2
Identifiers
SymbolsWNT2 ; INT1L1; IRP
External IDsOMIM: 147870 MGI: 98954 HomoloGene: 20719 ChEMBL: 1255132 GeneCards: WNT2 Gene
Orthologs
SpeciesHumanMouse
Entrez747222413
EnsemblENSG00000105989ENSMUSG00000010797
UniProtP09544P21552
RefSeq (mRNA)NM_003391NM_023653
RefSeq (protein)NP_003382NP_076142
Location (UCSC)Chr 7:
116.92 – 116.96 Mb		Chr 6:
17.99 – 18.03 Mb
PubMed search

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.[1][2]

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2".
  2. ↑ Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS (June 1988). "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless". EMBO J. 7 (6): 1743–8. PMC 457162. PMID 2971536.

Further reading

  • Katoh M (2003). "WNT2 and human gastrointestinal cancer (review).". Int. J. Mol. Med. 12 (5): 811–6. doi:10.3892/ijmm.12.5.811. PMID 14533014.
  • Li J, Nguyen L, Gleason C et al. (2004). "Lack of evidence for an association between WNT2 and RELN polymorphisms and autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 126B (1): 51–7. doi:10.1002/ajmg.b.20122. PMID 15048648.
  • Pu P, Zhang Z, Kang C et al. (2009). "Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth.". Cancer Gene Ther. 16 (4): 351–61. doi:10.1038/cgt.2008.78. PMID 18949017.
  • Kodo K, Nishizawa T, Furutani M et al. (2009). "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 13933–8. doi:10.1073/pnas.0904744106. PMC 2728998. PMID 19666519.
  • Clément G, Braunschweig R, Pasquier N et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus.". Oncogene 25 (21): 3084–92. doi:10.1038/sj.onc.1209338. PMID 16407829.
  • Park JK, Song JH, He TC et al. (2009). "Overexpression of Wnt-2 in colorectal cancers.". Neoplasma 56 (2): 119–23. doi:10.4149/neo_2009_02_119. PMID 19239325.
  • Flahaut M, Meier R, Coulon A et al. (2009). "The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.". Oncogene 28 (23): 2245–56. doi:10.1038/onc.2009.80. PMID 19421142.
  • Liu ZL, Li Y, Kong QY et al. (2008). "Immunohistochemical profiling of Wnt, NF-kappaB, Stat3 and Notch signaling in human epidermal tumors.". J. Dermatol. Sci. 52 (2): 133–6. doi:10.1016/j.jdermsci.2008.06.011. PMID 18703315.
  • Kloth JN, Fleuren GJ, Oosting J et al. (2005). "Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines.". Carcinogenesis 26 (9): 1493–502. doi:10.1093/carcin/bgi110. PMID 15878915.
  • Mazieres J, You L, He B et al. (2005). "Wnt2 as a new therapeutic target in malignant pleural mesothelioma.". Int. J. Cancer 117 (2): 326–32. doi:10.1002/ijc.21160. PMID 15900580.
  • Wang HX, Tekpetey FR, Kidder GM (2009). "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.". Mol. Hum. Reprod. 15 (1): 11–7. doi:10.1093/molehr/gan070. PMID 19038973.
  • Han JC, Zhang KL, Chen XY et al. (2007). "Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling.". APMIS 115 (12): 1331–43. doi:10.1111/j.1600-0643.2007.00695.x. PMID 18184402.
  • Planutis K, Planutiene M, Moyer MP et al. (2007). "Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells.". BMC Cell Biol. 8: 12. doi:10.1186/1471-2121-8-12. PMC 1847812. PMID 17386109.
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cheng XX, Wang ZC, Chen XY et al. (2005). "Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin.". Clin. Exp. Metastasis 22 (1): 85–93. doi:10.1007/s10585-005-4578-8. PMID 16132582.
  • Shi Y, He B, Kuchenbecker KM et al. (2007). "Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.". Int. J. Cancer 121 (6): 1175–81. doi:10.1002/ijc.22848. PMID 17534895.
  • Cheng XX, Wang ZC, Chen XY et al. (2005). "Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination.". Cancer Lett. 223 (2): 339–47. doi:10.1016/j.canlet.2004.11.013. PMID 15896469.
  • Ma XR, Edmund Sim UH, Pauline B et al. (2008). "Overexpression of WNT2 and TSG101 genes in colorectal carcinoma.". Tropical biomedicine 25 (1): 46–57. PMID 18600204.
  • de Krom M, Staal WG, Ophoff RA et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder.". Biol. Psychiatry 65 (7): 625–30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.