WDR45L
| WD repeat domain 45B | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | WDR45B ; WDR45L; WIPI-3; WIPI3 | ||||||||||||
| External IDs | OMIM: 609226 MGI: 1914090 HomoloGene: 6028 GeneCards: WDR45B Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56270 | 66840 | |||||||||||
| Ensembl | ENSG00000141580 | ENSMUSG00000025173 | |||||||||||
| UniProt | Q5MNZ6 | Q9CR39 | |||||||||||
| RefSeq (mRNA) | NM_019613 | NM_025793 | |||||||||||
| RefSeq (protein) | NP_062559 | NP_080069 | |||||||||||
| Location (UCSC) | Chr 17: 80.57 – 80.61 Mb | Chr 11: 121.33 – 121.35 Mb | |||||||||||
| PubMed search | |||||||||||||
WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.[1]
Structure and function
WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.[1]
See also
References
Further reading
- Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Jeffries TR, Dove SK, Michell RH, Parker PJ (2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.". Mol. Biol. Cell 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
- Proikas-Cezanne T, Waddell S, Gaugel A, et al. (2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.". Oncogene 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.