Vorozole

Vorozole

Systematic (IUPAC) name
6-[(4-Chlorophenyl)(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole
Clinical data
Pharmacokinetic data
Bioavailability	Very high
Metabolism	Hepatic
Half-life	8 hours
Identifiers
CAS Registry Number	118949-22-7 N
ATC code	L02BG05
PubChem	CID 6918191
ChemSpider	5293402 Y
UNII	1E2S9YXV2A Y
KEGG	D03786 Y
ChEMBL	CHEMBL224060 Y
Chemical data
Formula	C16H13ClN6
Molecular mass	324.768 g/mol
SMILES Clc1ccc(cc1)[C@@H](c2ccc3nnn(c3c2)C)n4ncnc4
N (what is this?)  (verify)

Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

It is selective.^[1]

References