Very long chain fatty acid
A very long chain fatty acid (VLCFA) is a fatty acid with aliphatic tails longer than 22 carbons.
Unlike most fatty acids, VLCFAs are too long to be metabolized in the mitochondria, and must be metabolized in peroxisomes.
Certain peroxisomal disorders, such as adrenoleukodystrophy, can be associated with an accumulation of VLCFAs.[1][2]
See also
References
Bibliography
- Moser, H. W.; Moser, A. B.; Frayer, K. K.; Chen, W.; Schulman, J. D.; O'Neill, B. P.; Kishimoto, Y. (1981). "Adrenoleukodystrophy: Increased plasma content of saturated very long chain fatty acids". Neurology 31 (10): 1241–1241. doi:10.1212/WNL.31.10.1241. ISSN 0028-3878.
|
---|
| Synthesis | |
---|
| Degradation | |
---|
| Peroxisomal | |
---|
| |
---|
| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
|
---|
| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
|
---|
| Treatment | |
---|
|
---|
| Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
|
---|
| Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
|
---|
| Nucleic acids | |
---|
| Proteins | |
---|
| Other |
- Tetrapyrroles
- intermediates
|
---|
|
|