Vasomotion

Vasomotion is the spontaneous oscillation in tone of blood vessels, independent of heart beat, innervation or respiration.[1] While vasomotion was first observed by Jones in 1852, the complete mechanisms responsible for its generation and its physiological importance remain to be elucidated, however several hypotheses have been put forth.[2]

Mechanism

Intracellular calcium (Ca2+) concentration exhibits periodic oscillations in vascular smooth muscle cells. This is thought to result from Ca2+ release from intracellular stores, due to inositol triphosphate and ryanodine-sensitive channel activation. This activation has been shown to result in either Ca2+ "sparks", highly localized calcium increases, or "waves", global Ca2+ increase that propagates the length of the cell.[3]

To allow vasomotion to occur, synchronization must occur between the individual oscillations, resulting in global calcium synchronization and vessel tone oscillation.[4] Gap junctions are thought to play a large role in this synchronization, as application of gap junction blockers has been shown to abolish vasomotion, indicating a critical role.[5] Due to regional variations in gap junction distribution and coupling (homocellular vs. heterocellular) several hypotheses have been suggested to account for vasomotion occurrence.

The "classic" mechanism of vasomotion generation is thought to be the voltage-dependent coupled model.[4] In this model, high gap junction coupling is present between the vascular smooth muscle cells, the endothelial cells and the endothelial to vascular smooth muscle cells. An initial depolarizing current leads to the opening of the voltage-dependent calcium channels, ultimately resulting in synchronization of individual calcium levels. When patch clamp recordings are conducted, depolarization occurs in the endothlial layer at the same time as the underlying vascular smooth muscle. The cause of the initial depolarizing current, however, remains to be determined. Mathematical modeling has pointed to the existence of 2-4 independent non-linear oscillating systems interacting to produce vasomotion.[6] It is possible that in order for vasomotion to be generated, these systems must pass a depolarizing threshold.

Physiological role

Several possible hypotheses have been advanced to explain vasomotion. Increased flow is one possibility; mathematical modeling has shown a vessel with an oscillating diameter to conduct more flow then a vessel with a static diameter.[7] Vasomotion could also be a mechanism of increasing the reactivity of a blood vessel by avoiding the "latch state", a low ATP cycling state of prolonged force generation common in vascular smooth muscle. Finally, vasomotion has been shown to be altered in a variety of pathological situations, with vessels from both hypertensive and diabetic patients displaying altered flow patterns as compared to normotensive vessels.[8]

References

  1. ↑ Haddock RE, Hill CE. Rhythmicity in arterial smooth muscle. J Physiol (Lond ). 2005; 566: 645-656,Aalkaer C, Nilsson H. Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br J Pharmacol. 2005; 144: 605-616.
  2. ↑ Aalkaer C, Nilsson H. Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br J Pharmacol. 2005; 144: 605-616.
  3. ↑ Jaggar JH, Porter VA, Lederer WJ, Nelson MT. Calcium sparks in smooth muscle. Am J Physiol Cell Physiol. 2000; 278: C235-256.
  4. ↑ 4.0 4.1 Nilsson H, Aalkjaer C. Vasomotion: mechanisms and physiological importance. Molecular Interventions. 2003; 3: 79-89.
  5. ↑ Haddock RE, Hirst GDS, Hill CE. Voltage independence of vasomotion in isolated irideal arterioles of the rat. J Physiol. 2002; 540: 219-229.
  6. ↑ Parthimos D, Haddock RE, Hill CE, Griffith TM. Dynamics of A Three-Variable Nonlinear Model of Vasomotion: Comparison of Theory and Experiment. Biophys J. 2007; 93: 1534-1556.
  7. ↑ Meyer C, de Vries G, Davidge ST, Mayes DC. Reassessing the Mathematical Modeling of the Contribution of Vasomotion to Vascular Resistance. J Appl Physiol. 2002; 92: 888-889.
  8. ↑ Gratton RJ, Gandley RE, McCarthy JF, Michaluk WK, Slinker BK, McLaughlin MK. Contribution of vasomotion to vascular resistance: a comparison of arteries from virgin and pregnant rats. J Appl Physiol. 1998; 85: 2255-2260.

See also