VSX2

Visual system homeobox 2

Identifiers

VSX2 ; CHX10; HOX10; MCOP2; MCOPCB3; RET1

External IDs

OMIM: 142993 MGI: 88401 HomoloGene: 7266 GeneCards: VSX2 Gene

Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• nucleus • cytoplasm
Biological process	• transcription, DNA-templated • visual perception • positive regulation of cell proliferation • negative regulation of cell proliferation • cell fate commitment • positive regulation of transcription from RNA polymerase II promoter • response to stimulus • retinal bipolar neuron differentiation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000119614

ENSMUSG00000021239

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
74.71 – 74.73 Mb

Chr 12:
84.57 – 84.6 Mb

PubMed search

Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene.^[1]^[2]

References

↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

Further reading

"Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Ferda Percin E, Ploder LA, Yu JJ et al. (2000). "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.". Nat. Genet. 25 (4): 397–401. doi:10.1038/78071. PMID 10932181.
Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.". J. Biol. Chem. 276 (6): 4109–18. doi:10.1074/jbc.M008882200. PMID 11069920.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Bar-Yosef U, Abuelaish I, Harel T et al. (2005). "CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds.". Hum. Genet. 115 (4): 302–9. doi:10.1007/s00439-004-1154-2. PMID 15257456.
Dorval KM, Bobechko BP, Ahmad KF, Bremner R (2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1.". J. Biol. Chem. 280 (11): 10100–8. doi:10.1074/jbc.M412676200. PMID 15647262.
Kuiper H, Spötter A, Williams JL et al. (2005). "Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34.". Cytogenet. Genome Res. 109 (4): 533. doi:10.1159/000084217. PMID 15909363.
Dorval KM, Bobechko BP, Fujieda H et al. (2006). "CHX10 targets a subset of photoreceptor genes.". J. Biol. Chem. 281 (2): 744–51. doi:10.1074/jbc.M509470200. PMID 16236706.
Faiyaz-Ul-Haque M, Zaidi SH, Al-Mureikhi MS et al. (2007). "Mutations in the CHX10 gene in non-syndromic microphthalmia/anophthalmia patients from Qatar.". Clin. Genet. 72 (2): 164–6. doi:10.1111/j.1399-0004.2007.00846.x. PMID 17661825.

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