VPS24
| Charged multivesicular body protein 3 | |||||||||||||
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 PDB rendering based on 2gd5. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CHMP3 ; NEDF; VPS24 | ||||||||||||
| External IDs | OMIM: 610052 MGI: 1913950 HomoloGene: 6368 GeneCards: CHMP3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51652 | 66700 | |||||||||||
| Ensembl | ENSG00000115561 | ENSMUSG00000053119 | |||||||||||
| UniProt | Q9Y3E7 | Q9CQ10 | |||||||||||
| RefSeq (mRNA) | NM_001005753 | NM_025783 | |||||||||||
| RefSeq (protein) | NP_001005753 | NP_080059 | |||||||||||
| Location (UCSC) | Chr 2: 86.73 – 86.95 Mb | Chr 6: 71.54 – 71.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[1][2][3]
Function
This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]
Interactions
VPS24 has been shown to interact with IGFBP7.[1]
References
- ↑ 1.0 1.1 Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700.
- ↑ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588.
- ↑ 3.0 3.1 "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)".
Further reading
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD (2002). "Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting". Dev. Cell 3 (2): 271–82. doi:10.1016/S1534-5807(02)00220-4. PMID 12194857.
- Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ et al. (2003). "Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization". J. Neurovirol. 9 (3): 372–89. doi:10.1080/713831538. PMID 12775420.
- Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. Vancouver style error (help)
- von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E et al. (2003). "The protein network of HIV budding". Cell 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. Vancouver style error (help)
- Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1". J. Biol. Chem. 280 (13): 12799–809. doi:10.1074/jbc.M413968200. PMID 15632132.
- Yan Q, Hunt PR, Frelin L, Vida TA, Pevsner J, Bean AJ (2005). "mVps24p functions in EGF receptor sorting/trafficking from the early endosome". Exp. Cell Res. 304 (1): 265–73. doi:10.1016/j.yexcr.2004.11.003. PMID 15707591.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Walker GE, Antoniono RJ, Ross HJ, Paisley TE, Oh Y (2006). "Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1". Oncogene 25 (13): 1943–54. doi:10.1038/sj.onc.1209213. PMID 16302002.
- Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D et al. (2006). "The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor". Mol. Biol. Cell 17 (6): 2513–23. doi:10.1091/mbc.E05-10-0915. PMC 1474783. PMID 16554368. Vancouver style error (help)
- Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Zamborlini A, Usami Y, Radoshitzky SR, Popova E, Palu G, Göttlinger H (2007). "Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 19140–5. doi:10.1073/pnas.0603788103. PMC 1748189. PMID 17146056. Vancouver style error (help)
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