VDAC2

Voltage-dependent anion channel 2
Identifiers
SymbolsVDAC2 ; POR
External IDsOMIM: 193245 MGI: 106915 HomoloGene: 37765 ChEMBL: 6190 GeneCards: VDAC2 Gene
Orthologs
SpeciesHumanMouse
Entrez741722334
EnsemblENSG00000165637ENSMUSG00000021771
UniProtP45880Q60930
RefSeq (mRNA)NM_001184783NM_011695
RefSeq (protein)NP_001171712NP_035825
Location (UCSC)Chr 10:
76.97 – 76.99 Mb		Chr 14:
21.83 – 21.85 Mb
PubMed search

Voltage-dependent anion-selective channel protein 2 is a protein that in humans is encoded by the VDAC2 gene.[1][2] The protein encoded by this gene is a voltage-dependent anion channel.[1][2]

VDAC2 is involved in the regulation of mitochondrial apoptosis.[3]

References

  1. ↑ 1.0 1.1 Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (Jul 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385.
  2. ↑ 2.0 2.1 Messina A, Oliva M, Rosato C, Huizing M, Ruitenbeek W, van den Heuvel LP, Forte M, Rocchi M, De Pinto V (Apr 1999). "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered". Biochem Biophys Res Commun 255 (3): 707–10. doi:10.1006/bbrc.1998.0136. PMID 10049775.
  3. ↑ Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (July 2003). "VDAC2 inhibits BAK activation and mitochondrial apoptosis". Science 301 (5632): 513–7. doi:10.1126/science.1083995. PMID 12881569.

Further reading

  • Blachly-Dyson E, Zambronicz EB, Yu WH et al. (1993). "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.". J. Biol. Chem. 268 (3): 1835–41. PMID 8420959.
  • Valis K, Neubauerova J, Man P et al. (2008). "VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation.". Mol. Cell. Biochem. 311 (1-2): 225–31. doi:10.1007/s11010-008-9712-x. PMID 18278581.
  • Mannella CA (1998). "Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications.". J. Struct. Biol. 121 (2): 207–18. doi:10.1006/jsbi.1997.3954. PMID 9615439.
  • Bogenhagen DF, Rousseau D, Burke S (2008). "The layered structure of human mitochondrial DNA nucleoids.". J. Biol. Chem. 283 (6): 3665–75. doi:10.1074/jbc.M708444200. PMID 18063578.
  • Chandra D, Choy G, Daniel PT, Tang DG (2005). "Bax-dependent regulation of Bak by voltage-dependent anion channel 2.". J. Biol. Chem. 280 (19): 19051–61. doi:10.1074/jbc.M501391200. PMID 15757910.
  • Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Yoo BC, Fountoulakis M, Cairns N, Lubec G (2001). "Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome.". Electrophoresis 22 (1): 172–9. doi:10.1002/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P. PMID 11197169.
  • Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.
  • Ha H, Hajek P, Bedwell DM, Burrows PD (1993). "A mitochondrial porin cDNA predicts the existence of multiple human porins.". J. Biol. Chem. 268 (16): 12143–9. PMID 7685033.
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yu WH, Wolfgang W, Forte M (1995). "Subcellular localization of human voltage-dependent anion channel isoforms.". J. Biol. Chem. 270 (23): 13998–4006. doi:10.1074/jbc.270.23.13998. PMID 7539795.
  • Hinsch KD, De Pinto V, Aires VA et al. (2004). "Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.". J. Biol. Chem. 279 (15): 15281–8. doi:10.1074/jbc.M313433200. PMID 14739283.
  • Decker WK, Bowles KR, Schatte EC et al. (1999). "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.". Mamm. Genome 10 (10): 1041–2. doi:10.1007/s003359901158. PMID 10501981.
  • Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Bernhard OK, Cunningham AL, Sheil MM (2004). "Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.". J. Am. Soc. Mass Spectrom. 15 (4): 558–67. doi:10.1016/j.jasms.2003.12.006. PMID 15047060.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
  • Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links