Uroguanylin

guanylate cyclase activator 2B (uroguanylin)
Identifiers
Symbol	GUCA2B
Entrez	2981
HUGO	4683
OMIM	601271
RefSeq	NM_007102
UniProt	Q16661
Other data
Locus	Chr. 1 p34-p33

Uroguanylin
Identifiers

CAS Registry Number	152175-68-3^Y
ChemSpider	4589972^Y
InChI InChI=1S/C61H101N17O25S4/c1-9-26(6)46(60(101)72-33(17-40(64)81)54(95)76-45(25(4)5)59(100)66-27(7)48(89)73-36(21-105)57(98)78-47(28(8)79)58(99)65-19-41(82)67-38(23-107)61(102)103)77-56(97)37(22-106)75-52(93)32(16-24(2)3)70-51(92)31(12-15-43(85)86)69-55(96)35(20-104)74-53(94)34(18-44(87)88)71-50(91)30(11-14-42(83)84)68-49(90)29(62)10-13-39(63)80/h24-38,45-47,79,104-107H,9-23,62H2,1-8H3,(H2,63,80)(H2,64,81)(H,65,99)(H,66,100)(H,67,82)(H,68,90)(H,69,96)(H,70,92)(H,71,91)(H,72,101)(H,73,89)(H,74,94)(H,75,93)(H,76,95)(H,77,97)(H,78,98)(H,83,84)(H,85,86)(H,87,88)(H,102,103)/t26-,27-,28+,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,45-,46-,47-/m0/s1^Y Key: SJMPVWVIVWEWJK-AXEIBBKLSA-N^Y
Jmol-3D images	Image
MeSH	uroguanylin
PubChem	5488765
SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CS)C(O)=O
Properties
Molecular formula	C₆₁H₁₀₁N₁₇O₂₅S₄
Molar mass	1,600.81 g·mol⁻¹
Related compounds
Related compounds	PMDTA
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.^[1]^[2]

References

↑ Miyazato, M.; Nakazato, M.; Yamaguchi, H.; Date, Y.; Kojima, M.; Kangawa, K.; Matsuo, H.; Matsukura, S. (Feb 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.". Biochem Biophys Res Commun 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
↑ Miyazato, M.; Nakazato, M.; Matsukura, S.; Kangawa, K.; Matsuo, H. (Aug 1997). "Genomic structure and chromosomal localization of human uroguanylin.". Genomics 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.

External links

uroguanylin at the US National Library of Medicine Medical Subject Headings (MeSH)

Uroguanylin

See also

References

External links