UTX (gene)

Lysine (K)-specific demethylase 6A

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3AVR, 3AVS

Identifiers

Symbols

KDM6A ; KABUK2; UTX; bA386N14.2

External IDs

OMIM: 300128 MGI: 1095419 HomoloGene: 7586 IUPHAR: 2684 GeneCards: KDM6A Gene

Gene ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding • metal ion binding • dioxygenase activity • histone demethylase activity (H3-K27 specific)
Cellular component	• nucleus • histone methyltransferase complex
Biological process	• in utero embryonic development • neural tube closure • respiratory system process • heart development • somite rostral/caudal axis specification • mesodermal cell differentiation • notochord morphogenesis • histone H3-K4 methylation • oxidation-reduction process • canonical Wnt signaling pathway • histone H3-K27 demethylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
44.73 – 44.97 Mb

Chr X:
18.16 – 18.28 Mb

PubMed search

Ubiquitously transcribed tetratricopeptide repeat, X chromosome, also known as UTX, is a protein which in humans is encoded by the UTX gene.^[1]^[2]^[3]

Function

UTX has been linked with histone demethylation, a potential means of regulating cellular metabolism.^[4]

References

↑ "Entrez Gene: UTX ubiquitously transcribed tetratricopeptide repeat, X chromosome".
↑ Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
↑ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (April 1998). "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
↑ Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R (October 2007). "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination". Science 318 (5849): 447–50. doi:10.1126/science.1149042. PMID 17761849.

Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome.". Science 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
Greenfield A, Carrel L, Pennisi D et al. (1998). "The UTX gene escapes X inactivation in mice and humans.". Hum. Mol. Genet. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
Grbavec D, Lo R, Liu Y et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 ( Pt 1) (Pt 1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerrard DT, Filatov DA (2005). "Positive and negative selection on mammalian Y chromosomes". Mol. Biol. Evol. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.
Cho YW, Hong T, Hong S et al. (2007). "PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex". J. Biol. Chem. 282 (28): 20395–406. doi:10.1074/jbc.M701574200. PMC 2729684. PMID 17500065.
Agger K, Cloos PA, Christensen J et al. (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature 449 (7163): 731–4. doi:10.1038/nature06145. PMID 17713478.
Lee MG, Villa R, Trojer P et al. (2007). "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination". Science 318 (5849): 447–50. doi:10.1126/science.1149042. PMID 17761849.
Lan F, Bayliss PE, Rinn JL et al. (2007). "A histone H3 lysine 27 demethylase regulates animal posterior development". Nature 449 (7163): 689–94. doi:10.1038/nature06192. PMID 17851529.
Hong S, Cho YW, Yu LR et al. (2008). "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18439–44. doi:10.1073/pnas.0707292104. PMC 2141795. PMID 18003914.

UTX (gene)

Function

References

Further reading